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Effect of a 2-week interruption in methotrexate treatment versus continued treatment on COVID-19 booster vaccine immunity in adults with inflammatory conditions (VROOM study): a randomised, open label, superiority trial

BACKGROUND: Immunosuppressive treatments inhibit vaccine-induced immunity against SARS-CoV-2. We evaluated whether a 2-week interruption of methotrexate treatment immediately after the COVID-19 vaccine booster improved antibody responses against the S1 receptor-binding domain (S1-RBD) of the SARS-Co...

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Detalles Bibliográficos
Autores principales:	Abhishek, Abhishek, Boyton, Rosemary J, Peckham, Nicholas, McKnight, Áine, Coates, Laura C, Bluett, James, Barber, Vicki, Cureton, Lucy, Francis, Anne, Appelbe, Duncan, Eldridge, Lucy, Julier, Patrick, Valdes, Ana M, Brooks, Tim, Rombach, Ines, Altmann, Daniel M, Nguyen-Van-Tam, Jonathan S, Williams, Hywel C, Cook, Jonathan A
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Author(s). Published by Elsevier Ltd. 2022
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236568/ https://www.ncbi.nlm.nih.gov/pubmed/35772416 http://dx.doi.org/10.1016/S2213-2600(22)00186-2

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