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Quantitative prediction of variant effects on alternative splicing in MAPT using endogenous pre-messenger RNA structure probing

Splicing is highly regulated and is modulated by numerous factors. Quantitative predictions for how a mutation will affect precursor mRNA (pre-mRNA) structure and downstream function are particularly challenging. Here, we use a novel chemical probing strategy to visualize endogenous precursor and ma...

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Detalles Bibliográficos
Autores principales:	Kumar, Jayashree, Lackey, Lela, Waldern, Justin M, Dey, Abhishek, Mustoe, Anthony M, Weeks, Kevin M, Mathews, David H, Laederach, Alain
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	eLife Sciences Publications, Ltd 2022
Materias:	Computational and Systems Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236610/ https://www.ncbi.nlm.nih.gov/pubmed/35695373 http://dx.doi.org/10.7554/eLife.73888

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