Cystathionine-β-synthase is essential for AKT-induced senescence and suppresses the development of gastric cancers with PI3K/AKT activation

Hyperactivation of oncogenic pathways downstream of RAS and PI3K/AKT in normal cells induces a senescence-like phenotype that acts as a tumor-suppressive mechanism that must be overcome during transformation. We previously demonstrated that AKT-induced senescence (AIS) is associated with profound tr...

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Detalles Bibliográficos
Autores principales: Zhu, Haoran, Chan, Keefe T, Huang, Xinran, Cerra, Carmelo, Blake, Shaun, Trigos, Anna S, Anderson, Dovile, Creek, Darren J, De Souza, David P, Wang, Xi, Fu, Caiyun, Jana, Metta, Sanij, Elaine, Pearson, Richard B, Kang, Jian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236611/
https://www.ncbi.nlm.nih.gov/pubmed/35758651
http://dx.doi.org/10.7554/eLife.71929

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