Cargando…

GMP Compliant Production of a Cryopreserved Adipose-Derived Stromal Cell Product for Feasible and Allogeneic Clinical Use

The emerging field of advanced therapy medicinal products (ATMP) holds promise of treating a variety of diseases. Adipose-derived stromal cells (ASCs) are currently being marketed or tested as cell-based therapies in numerous clinical trials. To ensure safety and efficacy of treatments, high-quality...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haack-Sørensen, Mandana, Johansen, Ellen Mønsted, Højgaard, Lisbeth Drozd, Kastrup, Jens, Ekblond, Annette
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236818/ https://www.ncbi.nlm.nih.gov/pubmed/35769340 http://dx.doi.org/10.1155/2022/4664917

Ejemplares similares

Cryopreserved Off‐the‐Shelf Allogeneic Adipose‐Derived Stromal Cells for Therapy in Patients with Ischemic Heart Disease and Heart Failure—A Safety Study
por: Kastrup, Jens, et al.
Publicado: (2017)

Rationale and Design of the First Double-Blind, Placebo-Controlled Trial with Allogeneic Adipose Tissue-Derived Stromal Cell Therapy in Patients with Ischemic Heart Failure: A Phase II Danish Multicentre Study
por: Kastrup, Jens, et al.
Publicado: (2017)

Adipose-derived stromal cells increase the formation of collagens through paracrine and juxtacrine mechanisms in a fibroblast co-culture model utilizing macromolecular crowding
por: Søndergaard, Rebekka Harary, et al.
Publicado: (2022)

Danish phase II trial using adipose tissue derived mesenchymal stromal cells for patients with ischaemic heart failure
por: Qayyum, Abbas Ali, et al.
Publicado: (2023)

The Initial Cardiac Tissue Response to Cryopreserved Allogeneic Adipose Tissue-Derived Mesenchymal Stromal Cells in Rats with Chronic Ischemic Cardiomyopathy
por: Follin, Bjarke, et al.
Publicado: (2021)

Optimizing an immunomodulatory potency assay for Mesenchymal Stromal Cell
por: Hansen, Stine Bangsgaard, et al.
Publicado: (2022)

Identical effects of VEGF and serum-deprivation on phenotype and function of adipose-derived stromal cells from healthy donors and patients with ischemic heart disease
por: Follin, Bjarke, et al.
Publicado: (2013)

Autologous adipose-derived stromal cell treatment for patients with refractory angina (MyStromalCell Trial): 3-years follow-up results
por: Qayyum, Abbas Ali, et al.
Publicado: (2019)

Identification of a common reference gene pair for qPCR in human mesenchymal stromal cells from different tissue sources treated with VEGF
por: Tratwal, Josefine, et al.
Publicado: (2014)

Culture expansion of adipose derived stromal cells. A closed automated Quantum Cell Expansion System compared with manual flask-based culture
por: Haack-Sørensen, Mandana, et al.
Publicado: (2016)

Retention and Functional Effect of Adipose-Derived Stromal Cells Administered in Alginate Hydrogel in a Rat Model of Acute Myocardial Infarction
por: Follin, Bjarke, et al.
Publicado: (2018)

GMP-Compliant Production of Autologous Adipose-Derived Stromal Cells in the NANT 001 Closed Automated Bioreactor
por: Fitzgerald, Joan C., et al.
Publicado: (2022)

Adipose-Derived Stromal Cells for Treatment of Patients with Chronic Ischemic Heart Disease (MyStromalCell Trial): A Randomized Placebo-Controlled Study
por: Qayyum, Abbas Ali, et al.
Publicado: (2017)

Improved GMP compliant approach to manipulate lipoaspirates, to cryopreserve stromal vascular fraction, and to expand adipose stem cells in xeno-free media
por: Agostini, Francesco, et al.
Publicado: (2018)

Adipose Tissue-Derived Stromal Cells Induce a Highly Trophic Environment While Reducing Maturation of Monocyte-Derived Dendritic Cells
por: Juhl, Morten, et al.
Publicado: (2020)

Influence of vascular endothelial growth factor stimulation and serum deprivation on gene activation patterns of human adipose tissue-derived stromal cells
por: Tratwal, Josefine, et al.
Publicado: (2015)

Standardized GMP-compliant scalable production of human pancreas organoids
por: Dossena, Marta, et al.
Publicado: (2020)

Cell-based medicinal products and the development of GMP-compliant processes and manufacturing
por: Romagnoli, Luca, et al.
Publicado: (2011)

A short-term plastic adherence incubation of the stromal vascular fraction leads to a predictable GMP-compliant cell-product
por: Born, Stephan, et al.
Publicado: (2019)

GMP-compliant production of [(68)Ga]Ga-NeoB for positron emission tomography imaging of patients with gastrointestinal stromal tumor
por: Pretze, Marc, et al.
Publicado: (2021)

Automated GMP compliant production of [(18)F]AlF-NOTA-octreotide
por: Tshibangu, Térence, et al.
Publicado: (2020)

Increased Paracrine Immunomodulatory Potential of Mesenchymal Stromal Cells in Three-Dimensional Culture
por: Follin, Bjarke, et al.
Publicado: (2016)

Long-Term Stability and Differentiation Potential of Cryopreserved cGMP-Compliant Human Induced Pluripotent Stem Cells
por: Shafa, Mehdi, et al.
Publicado: (2019)

Intraglandular Off-the-Shelf Allogeneic Mesenchymal Stem Cell Treatment in Patients with Radiation-Induced Xerostomia: A Safety Study (MESRIX-II)
por: Lynggaard, Charlotte Duch, et al.
Publicado: (2022)

Pilot Production of Mesenchymal Stem/Stromal Freeze-Dried Secretome for Cell-Free Regenerative Nanomedicine: A Validated GMP-Compliant Process
por: Bari, Elia, et al.
Publicado: (2018)

Production of GMP-Compliant Clinical Amounts of Copper-61 Radiopharmaceuticals from Liquid Targets
por: Fonseca, Alexandra I., et al.
Publicado: (2022)

Expansion of Human Tregs from Cryopreserved Umbilical Cord Blood for GMP-Compliant Autologous Adoptive Cell Transfer Therapy
por: Seay, Howard R., et al.
Publicado: (2016)

Automated GMP-Compliant Production of [(68)Ga]Ga-DO3A-Tuna-2 for PET Microdosing Studies of the Glucagon Receptor in Humans
por: Wagner, Michael, et al.
Publicado: (2020)

Optimised GMP-compliant production of [(18)F]DPA-714 on the Trasis AllinOne module
por: Cybulska, Klaudia A., et al.
Publicado: (2021)

Effectiveness and safety of mesenchymal stem/stromal cell for radiation-induced hyposalivation and xerostomia in previous head and neck cancer patients (MESRIX-III): a study protocol for a single-centre, double-blinded, randomised, placebo-controlled, phase II study
por: Jakobsen, Kathrine Kronberg, et al.
Publicado: (2023)

Evaluation of Tissue Homogenization to Support the Generation of GMP-Compliant Mesenchymal Stromal Cells from the Umbilical Cord
por: Emnett, Ryan J., et al.
Publicado: (2016)

Cryopreserved Allogeneic Adipose Improves Neo-dermal and Epidermal Thickness after Burns
por: Loder, Shawn, et al.
Publicado: (2021)

An Approach towards a GMP Compliant In-Vitro Expansion of Human Adipose Stem Cells for Autologous Therapies
por: Jossen, Valentin, et al.
Publicado: (2020)

Rationale and design of the European multicentre study on Stem Cell therapy in IschEmic Non‐treatable Cardiac diseasE (SCIENCE)
por: Paitazoglou, Christina, et al.
Publicado: (2019)

A Roadmap for the Production of a GMP-Compatible Cell Bank of Allogeneic Bone Marrow-Derived Clonal Mesenchymal Stromal Cells for Cell Therapy Applications
por: Pakzad, Mohammad, et al.
Publicado: (2022)

Improved GMP-compliant multi-dose production and quality control of 6-[(18)F]fluoro-L-DOPA
por: Luurtsema, G., et al.
Publicado: (2016)

Reproducibility of GMP-compliant production of therapeutic stressed peripheral blood mononuclear cell-derived secretomes, a novel class of biological medicinal products
por: Laggner, Maria, et al.
Publicado: (2020)

Lentivirus-induced ‘Smart' dendritic cells: Pharmacodynamics and GMP-compliant production for immunotherapy against TRP2-positive melanoma
por: Sundarasetty, B S, et al.
Publicado: (2015)

In Vivo MRI Tracking of Mesenchymal Stromal Cells Labeled with Ultrasmall Paramagnetic Iron Oxide Particles after Intramyocardial Transplantation in Patients with Chronic Ischemic Heart Disease
por: Mathiasen, Anders Bruun, et al.
Publicado: (2019)

GMP-Compliant, Large-Scale Expanded Allogeneic Natural Killer Cells Have Potent Cytolytic Activity against Cancer Cells In Vitro and In Vivo
por: Lim, Okjae, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_qak24sr14hfkafhk9ssm42c4j1