Impaired oxygen-sensitive regulation of mitochondrial biogenesis within the von Hippel–Lindau syndrome

Mitochondria are the main consumers of oxygen within the cell. How mitochondria sense oxygen levels remains unknown. Here we show an oxygen-sensitive regulation of TFAM, an activator of mitochondrial transcription and replication, whose alteration is linked to tumours arising in the von Hippel–Linda...

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Detalles Bibliográficos
Autores principales: Li, Shuijie, Li, Wenyu, Yuan, Juan, Bullova, Petra, Wu, Jieyu, Zhang, Xuepei, Liu, Yong, Plescher, Monika, Rodriguez, Javier, Bedoya-Reina, Oscar C., Jannig, Paulo R., Valente-Silva, Paula, Yu, Meng, Henriksson, Marie Arsenian, Zubarev, Roman A., Smed-Sörensen, Anna, Suzuki, Carolyn K., Ruas, Jorge L., Holmberg, Johan, Larsson, Catharina, Christofer Juhlin, C., von Kriegsheim, Alex, Cao, Yihai, Schlisio, Susanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236906/
https://www.ncbi.nlm.nih.gov/pubmed/35760869
http://dx.doi.org/10.1038/s42255-022-00593-x

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