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Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches

COVID-19 pandemic caused by the Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) has inflicted a global health challenge. Although the overwhelming escalation of mortality seen during the initial phase of the pandemic has reduced, emerging variants of SARS-CoV-2 continue to impact commu...

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Autores principales: Bhat, Swati, Rishi, Praveen, Chadha, Vijayta D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier B.V. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236910/
https://www.ncbi.nlm.nih.gov/pubmed/35777502
http://dx.doi.org/10.1016/j.virusres.2022.198853
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author Bhat, Swati
Rishi, Praveen
Chadha, Vijayta D
author_facet Bhat, Swati
Rishi, Praveen
Chadha, Vijayta D
author_sort Bhat, Swati
collection PubMed
description COVID-19 pandemic caused by the Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) has inflicted a global health challenge. Although the overwhelming escalation of mortality seen during the initial phase of the pandemic has reduced, emerging variants of SARS-CoV-2 continue to impact communities worldwide. Several studies have highlighted the association of gene specific epigenetic modifications in host cells with the pathogenesis and severity of the disease. Therefore, alongside the investigations into the virology and pathogenesis of SARS-CoV-2 infection, understanding the epigenetic mechanisms related to the disease is crucial for the rational design of effective targeted therapies. Here, we discuss the interaction of SARS-CoV-2 with the various epigenetic regulators and their subsequent contribution to the risk of disease severity and dysfunctional immune responses. Finally, we also highlight the use of epigenetically targeted drugs for the potential therapeutic interventions capable of eliminating viral infection and/or build effective immunity against it.
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spelling pubmed-92369102022-06-28 Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches Bhat, Swati Rishi, Praveen Chadha, Vijayta D Virus Res Article COVID-19 pandemic caused by the Severe acute respiratory syndrome coronavirus 2 (SARS- CoV-2) has inflicted a global health challenge. Although the overwhelming escalation of mortality seen during the initial phase of the pandemic has reduced, emerging variants of SARS-CoV-2 continue to impact communities worldwide. Several studies have highlighted the association of gene specific epigenetic modifications in host cells with the pathogenesis and severity of the disease. Therefore, alongside the investigations into the virology and pathogenesis of SARS-CoV-2 infection, understanding the epigenetic mechanisms related to the disease is crucial for the rational design of effective targeted therapies. Here, we discuss the interaction of SARS-CoV-2 with the various epigenetic regulators and their subsequent contribution to the risk of disease severity and dysfunctional immune responses. Finally, we also highlight the use of epigenetically targeted drugs for the potential therapeutic interventions capable of eliminating viral infection and/or build effective immunity against it. Elsevier B.V. 2022-09 2022-06-28 /pmc/articles/PMC9236910/ /pubmed/35777502 http://dx.doi.org/10.1016/j.virusres.2022.198853 Text en © 2022 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Bhat, Swati
Rishi, Praveen
Chadha, Vijayta D
Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches
title Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches
title_full Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches
title_fullStr Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches
title_full_unstemmed Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches
title_short Understanding the epigenetic mechanisms in SARS CoV-2 infection and potential therapeutic approaches
title_sort understanding the epigenetic mechanisms in sars cov-2 infection and potential therapeutic approaches
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236910/
https://www.ncbi.nlm.nih.gov/pubmed/35777502
http://dx.doi.org/10.1016/j.virusres.2022.198853
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