Impact of DYRK1A Expression on TNNT2 Splicing and Daunorubicin Toxicity in Human iPSC-Derived Cardiomyocytes

Cardiac troponin T (encoded by TNNT2) is involved in the contraction of cardiomyocytes during beating. The alternative splicing of TNNT2 results in four transcript variants with differential Ca(2+) sensitivity. The splicing of TNNT2 involves phosphorylation of the splicing factor SRSF6 by DYRK1A. Al...

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Detalles Bibliográficos
Autores principales: Cejas, Romina Beatriz, Tamaño-Blanco, Miriam, Fontecha, John Edgar, Blanco, Javier Guillermo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9236996/
https://www.ncbi.nlm.nih.gov/pubmed/35596909
http://dx.doi.org/10.1007/s12012-022-09746-6

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