High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature

The immune-pathology in Crohn’s disease is linked to dysregulated CD4+ T cell responses biased towards pathogenic TH17 cells. However, the role of CD8+ T cells able to produce IL-17 (Tc17 cells) remains unclear. Here we characterize the peripheral blood and intestinal tissue of Crohn’s disease patie...

Descripción completa

Detalles Bibliográficos
Autores principales: Globig, A.-M., Hipp, A. V., Otto-Mora, P., Heeg, M., Mayer, L. S., Ehl, S., Schwacha, H., Bewtra, M., Tomov, V., Thimme, R., Hasselblatt, P., Bengsch, B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237103/
https://www.ncbi.nlm.nih.gov/pubmed/35760777
http://dx.doi.org/10.1038/s41467-022-31229-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237103/
https://www.ncbi.nlm.nih.gov/pubmed/35760777
http://dx.doi.org/10.1038/s41467-022-31229-z

Ejemplares similares