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High-dimensional profiling reveals Tc17 cell enrichment in active Crohn’s disease and identifies a potentially targetable signature

The immune-pathology in Crohn’s disease is linked to dysregulated CD4+ T cell responses biased towards pathogenic TH17 cells. However, the role of CD8+ T cells able to produce IL-17 (Tc17 cells) remains unclear. Here we characterize the peripheral blood and intestinal tissue of Crohn’s disease patie...

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Detalles Bibliográficos
Autores principales:	Globig, A.-M., Hipp, A. V., Otto-Mora, P., Heeg, M., Mayer, L. S., Ehl, S., Schwacha, H., Bewtra, M., Tomov, V., Thimme, R., Hasselblatt, P., Bengsch, B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237103/ https://www.ncbi.nlm.nih.gov/pubmed/35760777 http://dx.doi.org/10.1038/s41467-022-31229-z

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