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Hsp multichaperone complex buffers pathologically modified Tau

Alzheimer’s disease is a neurodegenerative disorder in which misfolding and aggregation of pathologically modified Tau is critical for neuronal dysfunction and degeneration. The two central chaperones Hsp70 and Hsp90 coordinate protein homeostasis, but the nature of the interaction of Tau with the H...

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Detalles Bibliográficos
Autores principales:	Moll, Antonia, Ramirez, Lisa Marie, Ninov, Momchil, Schwarz, Juliane, Urlaub, Henning, Zweckstetter, Markus
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237115/ https://www.ncbi.nlm.nih.gov/pubmed/35760815 http://dx.doi.org/10.1038/s41467-022-31396-z

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