Genome-wide CRISPR screen identifies synthetic lethality between DOCK1 inhibition and metformin in liver cancer

Metformin is currently a strong candidate anti-tumor agent in multiple cancers. However, its anti-tumor effectiveness varies among different cancers or subpopulations, potentially due to tumor heterogeneity. It thus remains unclear which hepatocellular carcinoma (HCC) patient subpopulation(s) can be...

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Detalles Bibliográficos
Autores principales: Feng, Junru, Lu, Hui, Ma, Wenhao, Tian, Wenjing, Lu, Zhuan, Yang, Hongying, Cai, Yongping, Cai, Pengfei, Sun, Yuchen, Zhou, Zilong, Feng, Jiaqian, Deng, Jiazhong, Shu, Ying, Qu, Kun, Jia, Weidong, Gao, Ping, Zhang, Huafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237198/
https://www.ncbi.nlm.nih.gov/pubmed/35217990
http://dx.doi.org/10.1007/s13238-022-00906-6

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