Different Immunoregulation Roles of Activin A Compared With TGF-β

Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also transmits signals through SMAD2/SMAD3, howeve...

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Autores principales: Li, Fanglin, Long, Yiru, Yu, Xiaolu, Tong, Yongliang, Gong, Likun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237220/
https://www.ncbi.nlm.nih.gov/pubmed/35774793
http://dx.doi.org/10.3389/fimmu.2022.921366
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author Li, Fanglin
Long, Yiru
Yu, Xiaolu
Tong, Yongliang
Gong, Likun
author_facet Li, Fanglin
Long, Yiru
Yu, Xiaolu
Tong, Yongliang
Gong, Likun
author_sort Li, Fanglin
collection PubMed
description Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons with those of TGF-β.
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spelling pubmed-92372202022-06-29 Different Immunoregulation Roles of Activin A Compared With TGF-β Li, Fanglin Long, Yiru Yu, Xiaolu Tong, Yongliang Gong, Likun Front Immunol Immunology Activin A, a critical member of the transforming growth factor-β (TGF-β) superfamily, is a pluripotent factor involved in allergies, autoimmune diseases, cancers and other diseases with immune disorder. Similar to its family member, TGF-β, activin A also transmits signals through SMAD2/SMAD3, however, they bind to distinct receptors. Recent studies have uncovered that activin A plays a pivotal role in both innate and adaptive immune systems. Here we mainly focus its effects on activation, differentiation, proliferation and function of cells which are indispensable in the immune system and meanwhile make some comparisons with those of TGF-β. Frontiers Media S.A. 2022-06-14 /pmc/articles/PMC9237220/ /pubmed/35774793 http://dx.doi.org/10.3389/fimmu.2022.921366 Text en Copyright © 2022 Li, Long, Yu, Tong and Gong https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Li, Fanglin
Long, Yiru
Yu, Xiaolu
Tong, Yongliang
Gong, Likun
Different Immunoregulation Roles of Activin A Compared With TGF-β
title Different Immunoregulation Roles of Activin A Compared With TGF-β
title_full Different Immunoregulation Roles of Activin A Compared With TGF-β
title_fullStr Different Immunoregulation Roles of Activin A Compared With TGF-β
title_full_unstemmed Different Immunoregulation Roles of Activin A Compared With TGF-β
title_short Different Immunoregulation Roles of Activin A Compared With TGF-β
title_sort different immunoregulation roles of activin a compared with tgf-β
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237220/
https://www.ncbi.nlm.nih.gov/pubmed/35774793
http://dx.doi.org/10.3389/fimmu.2022.921366
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AT tongyongliang differentimmunoregulationrolesofactivinacomparedwithtgfb
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