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Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury

Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general surgery, is characterized by acute and rapid onset as well as high mortality, which often leads to multiple organ failure (MOF). Acute lung injury (ALI), the earliest accompanied organ dysfunction, is the most...

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Autores principales: Wang, Zhengjian, Li, Fan, Liu, Jin, Luo, Yalan, Guo, Haoya, Yang, Qi, Xu, Caiming, Ma, Shurong, Chen, Hailong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237221/
https://www.ncbi.nlm.nih.gov/pubmed/35774796
http://dx.doi.org/10.3389/fimmu.2022.913178
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author Wang, Zhengjian
Li, Fan
Liu, Jin
Luo, Yalan
Guo, Haoya
Yang, Qi
Xu, Caiming
Ma, Shurong
Chen, Hailong
author_facet Wang, Zhengjian
Li, Fan
Liu, Jin
Luo, Yalan
Guo, Haoya
Yang, Qi
Xu, Caiming
Ma, Shurong
Chen, Hailong
author_sort Wang, Zhengjian
collection PubMed
description Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general surgery, is characterized by acute and rapid onset as well as high mortality, which often leads to multiple organ failure (MOF). Acute lung injury (ALI), the earliest accompanied organ dysfunction, is the most common cause of death in patients following the SAP onset. The exact pathogenesis of ALI during SAP, however, remains unclear. In recent years, advances in the microbiota-gut-lung axis have led to a better understanding of SAP-associated lung injury (PALI). In addition, the bidirectional communications between intestinal microbes and the lung are becoming more apparent. This paper aims to review the mechanisms of an imbalanced intestinal microbiota contributing to the development of PALI, which is mediated by the disruption of physical, chemical, and immune barriers in the intestine, promotes bacterial translocation, and results in the activation of abnormal immune responses in severe pancreatitis. The pathogen-associated molecular patterns (PAMPs) mediated immunol mechanisms in the occurrence of PALI via binding with pattern recognition receptors (PRRs) through the microbiota-gut-lung axis are focused in this study. Moreover, the potential therapeutic strategies for alleviating PALI by regulating the composition or the function of the intestinal microbiota are discussed in this review. The aim of this study is to provide new ideas and therapeutic tools for PALI patients.
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spelling pubmed-92372212022-06-29 Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury Wang, Zhengjian Li, Fan Liu, Jin Luo, Yalan Guo, Haoya Yang, Qi Xu, Caiming Ma, Shurong Chen, Hailong Front Immunol Immunology Severe acute pancreatitis (SAP), one of the most serious abdominal emergencies in general surgery, is characterized by acute and rapid onset as well as high mortality, which often leads to multiple organ failure (MOF). Acute lung injury (ALI), the earliest accompanied organ dysfunction, is the most common cause of death in patients following the SAP onset. The exact pathogenesis of ALI during SAP, however, remains unclear. In recent years, advances in the microbiota-gut-lung axis have led to a better understanding of SAP-associated lung injury (PALI). In addition, the bidirectional communications between intestinal microbes and the lung are becoming more apparent. This paper aims to review the mechanisms of an imbalanced intestinal microbiota contributing to the development of PALI, which is mediated by the disruption of physical, chemical, and immune barriers in the intestine, promotes bacterial translocation, and results in the activation of abnormal immune responses in severe pancreatitis. The pathogen-associated molecular patterns (PAMPs) mediated immunol mechanisms in the occurrence of PALI via binding with pattern recognition receptors (PRRs) through the microbiota-gut-lung axis are focused in this study. Moreover, the potential therapeutic strategies for alleviating PALI by regulating the composition or the function of the intestinal microbiota are discussed in this review. The aim of this study is to provide new ideas and therapeutic tools for PALI patients. Frontiers Media S.A. 2022-06-14 /pmc/articles/PMC9237221/ /pubmed/35774796 http://dx.doi.org/10.3389/fimmu.2022.913178 Text en Copyright © 2022 Wang, Li, Liu, Luo, Guo, Yang, Xu, Ma and Chen https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Wang, Zhengjian
Li, Fan
Liu, Jin
Luo, Yalan
Guo, Haoya
Yang, Qi
Xu, Caiming
Ma, Shurong
Chen, Hailong
Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury
title Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury
title_full Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury
title_fullStr Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury
title_full_unstemmed Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury
title_short Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury
title_sort intestinal microbiota - an unmissable bridge to severe acute pancreatitis-associated acute lung injury
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237221/
https://www.ncbi.nlm.nih.gov/pubmed/35774796
http://dx.doi.org/10.3389/fimmu.2022.913178
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