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Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health

Developmental age is particularly vulnerable to impacts of environmental exposures. Until recent years, the field of environment and child health has predominantly relied on the study of single exposure–health effect relationships. The exposome is an emerging concept in epidemiology, encompassing th...

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Autores principales: Ferrante, Giuliana, Fasola, Salvatore, Cilluffo, Giovanna, Piacentini, Giorgio, Viegi, Giovanni, La Grutta, Stefania
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237327/
https://www.ncbi.nlm.nih.gov/pubmed/35774568
http://dx.doi.org/10.3389/fpubh.2022.871140
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author Ferrante, Giuliana
Fasola, Salvatore
Cilluffo, Giovanna
Piacentini, Giorgio
Viegi, Giovanni
La Grutta, Stefania
author_facet Ferrante, Giuliana
Fasola, Salvatore
Cilluffo, Giovanna
Piacentini, Giorgio
Viegi, Giovanni
La Grutta, Stefania
author_sort Ferrante, Giuliana
collection PubMed
description Developmental age is particularly vulnerable to impacts of environmental exposures. Until recent years, the field of environment and child health has predominantly relied on the study of single exposure–health effect relationships. The exposome is an emerging concept in epidemiology, encompassing the totality of the exposures experienced by an individual throughout life and their changes over time. This innovative approach provides a risk profile instead of individual predictors. Exposome research may contribute to better understand the complex relationships between environmental exposures and childhood respiratory health, in order to implement prevention strategies and mitigate adverse health outcomes across the life span. Indeed, an accurate assessment of the exposome needs several measurements as well as different technologies. High-throughput “omics” technologies may be promising tools to integrate a wide range of exposures. However, analyzing large and complex datasets requires the development of advanced statistical tools. This narrative review summarizes the current knowledge on exposome-based approaches in pediatric respiratory health. Further, it explores practical implementation, associated evidence gaps, research limitations and future research perspectives.
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spelling pubmed-92373272022-06-29 Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health Ferrante, Giuliana Fasola, Salvatore Cilluffo, Giovanna Piacentini, Giorgio Viegi, Giovanni La Grutta, Stefania Front Public Health Public Health Developmental age is particularly vulnerable to impacts of environmental exposures. Until recent years, the field of environment and child health has predominantly relied on the study of single exposure–health effect relationships. The exposome is an emerging concept in epidemiology, encompassing the totality of the exposures experienced by an individual throughout life and their changes over time. This innovative approach provides a risk profile instead of individual predictors. Exposome research may contribute to better understand the complex relationships between environmental exposures and childhood respiratory health, in order to implement prevention strategies and mitigate adverse health outcomes across the life span. Indeed, an accurate assessment of the exposome needs several measurements as well as different technologies. High-throughput “omics” technologies may be promising tools to integrate a wide range of exposures. However, analyzing large and complex datasets requires the development of advanced statistical tools. This narrative review summarizes the current knowledge on exposome-based approaches in pediatric respiratory health. Further, it explores practical implementation, associated evidence gaps, research limitations and future research perspectives. Frontiers Media S.A. 2022-06-14 /pmc/articles/PMC9237327/ /pubmed/35774568 http://dx.doi.org/10.3389/fpubh.2022.871140 Text en Copyright © 2022 Ferrante, Fasola, Cilluffo, Piacentini, Viegi and La Grutta. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Public Health
Ferrante, Giuliana
Fasola, Salvatore
Cilluffo, Giovanna
Piacentini, Giorgio
Viegi, Giovanni
La Grutta, Stefania
Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health
title Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health
title_full Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health
title_fullStr Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health
title_full_unstemmed Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health
title_short Addressing Exposome: An Innovative Approach to Environmental Determinants in Pediatric Respiratory Health
title_sort addressing exposome: an innovative approach to environmental determinants in pediatric respiratory health
topic Public Health
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237327/
https://www.ncbi.nlm.nih.gov/pubmed/35774568
http://dx.doi.org/10.3389/fpubh.2022.871140
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