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Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion

Cellular proteins directed to the plasma membrane or released into the extracellular space can undergo a number of different pathways. Whereas the molecular mechanisms that underlie conventional ER-to-Golgi trafficking are well established, those associated with the unconventional protein secretion...

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Autores principales: Noh, Shin Hye, Kim, Ye Jin, Lee, Min Goo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237382/
https://www.ncbi.nlm.nih.gov/pubmed/35774225
http://dx.doi.org/10.3389/fcell.2022.892450
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author Noh, Shin Hye
Kim, Ye Jin
Lee, Min Goo
author_facet Noh, Shin Hye
Kim, Ye Jin
Lee, Min Goo
author_sort Noh, Shin Hye
collection PubMed
description Cellular proteins directed to the plasma membrane or released into the extracellular space can undergo a number of different pathways. Whereas the molecular mechanisms that underlie conventional ER-to-Golgi trafficking are well established, those associated with the unconventional protein secretion (UPS) pathways remain largely elusive. A pathway with an emerging role in UPS is autophagy. Although originally known as a degradative process for maintaining intracellular homeostasis, recent studies suggest that autophagy has diverse biological roles besides its disposal function and that it is mechanistically involved in the UPS of various secretory cargos including both leaderless soluble and Golgi-bypassing transmembrane proteins. Here, we summarize current knowledge of the autophagy-related UPS pathways, describing and comparing diverse features in the autophagy-related UPS cargos and autophagy machineries utilized in UPS. Additionally, we also suggest potential directions that further research in this field can take.
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spelling pubmed-92373822022-06-29 Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion Noh, Shin Hye Kim, Ye Jin Lee, Min Goo Front Cell Dev Biol Cell and Developmental Biology Cellular proteins directed to the plasma membrane or released into the extracellular space can undergo a number of different pathways. Whereas the molecular mechanisms that underlie conventional ER-to-Golgi trafficking are well established, those associated with the unconventional protein secretion (UPS) pathways remain largely elusive. A pathway with an emerging role in UPS is autophagy. Although originally known as a degradative process for maintaining intracellular homeostasis, recent studies suggest that autophagy has diverse biological roles besides its disposal function and that it is mechanistically involved in the UPS of various secretory cargos including both leaderless soluble and Golgi-bypassing transmembrane proteins. Here, we summarize current knowledge of the autophagy-related UPS pathways, describing and comparing diverse features in the autophagy-related UPS cargos and autophagy machineries utilized in UPS. Additionally, we also suggest potential directions that further research in this field can take. Frontiers Media S.A. 2022-06-14 /pmc/articles/PMC9237382/ /pubmed/35774225 http://dx.doi.org/10.3389/fcell.2022.892450 Text en Copyright © 2022 Noh, Kim and Lee. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Noh, Shin Hye
Kim, Ye Jin
Lee, Min Goo
Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
title Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
title_full Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
title_fullStr Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
title_full_unstemmed Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
title_short Autophagy-Related Pathways in Vesicular Unconventional Protein Secretion
title_sort autophagy-related pathways in vesicular unconventional protein secretion
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237382/
https://www.ncbi.nlm.nih.gov/pubmed/35774225
http://dx.doi.org/10.3389/fcell.2022.892450
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