Cargando…
Proteolytic Activation of Plant Membrane-Bound Transcription Factors
Due to the presence of a transmembrane domain, the subcellular mobility plan of membrane-bound or membrane-tethered transcription factors (MB-TFs) differs from that of their cytosolic counterparts. The MB-TFs are mostly locked in (sub)cellular membranes, until they are released by a proteolytic clea...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237531/ https://www.ncbi.nlm.nih.gov/pubmed/35774815 http://dx.doi.org/10.3389/fpls.2022.927746 |
_version_ | 1784736816574758912 |
---|---|
author | De Backer, Jonas Van Breusegem, Frank De Clercq, Inge |
author_facet | De Backer, Jonas Van Breusegem, Frank De Clercq, Inge |
author_sort | De Backer, Jonas |
collection | PubMed |
description | Due to the presence of a transmembrane domain, the subcellular mobility plan of membrane-bound or membrane-tethered transcription factors (MB-TFs) differs from that of their cytosolic counterparts. The MB-TFs are mostly locked in (sub)cellular membranes, until they are released by a proteolytic cleavage event or when the transmembrane domain (TMD) is omitted from the transcript due to alternative splicing. Here, we review the current knowledge on the proteolytic activation mechanisms of MB-TFs in plants, with a particular focus on regulated intramembrane proteolysis (RIP), and discuss the analogy with the proteolytic cleavage of MB-TFs in animal systems. We present a comprehensive inventory of all known and predicted MB-TFs in the model plant Arabidopsis thaliana and examine their experimentally determined or anticipated subcellular localizations and membrane topologies. We predict proteolytically activated MB-TFs by the mapping of protease recognition sequences and structural features that facilitate RIP in and around the TMD, based on data from metazoan intramembrane proteases. Finally, the MB-TF functions in plant responses to environmental stresses and in plant development are considered and novel functions for still uncharacterized MB-TFs are forecasted by means of a regulatory network-based approach. |
format | Online Article Text |
id | pubmed-9237531 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-92375312022-06-29 Proteolytic Activation of Plant Membrane-Bound Transcription Factors De Backer, Jonas Van Breusegem, Frank De Clercq, Inge Front Plant Sci Plant Science Due to the presence of a transmembrane domain, the subcellular mobility plan of membrane-bound or membrane-tethered transcription factors (MB-TFs) differs from that of their cytosolic counterparts. The MB-TFs are mostly locked in (sub)cellular membranes, until they are released by a proteolytic cleavage event or when the transmembrane domain (TMD) is omitted from the transcript due to alternative splicing. Here, we review the current knowledge on the proteolytic activation mechanisms of MB-TFs in plants, with a particular focus on regulated intramembrane proteolysis (RIP), and discuss the analogy with the proteolytic cleavage of MB-TFs in animal systems. We present a comprehensive inventory of all known and predicted MB-TFs in the model plant Arabidopsis thaliana and examine their experimentally determined or anticipated subcellular localizations and membrane topologies. We predict proteolytically activated MB-TFs by the mapping of protease recognition sequences and structural features that facilitate RIP in and around the TMD, based on data from metazoan intramembrane proteases. Finally, the MB-TF functions in plant responses to environmental stresses and in plant development are considered and novel functions for still uncharacterized MB-TFs are forecasted by means of a regulatory network-based approach. Frontiers Media S.A. 2022-06-14 /pmc/articles/PMC9237531/ /pubmed/35774815 http://dx.doi.org/10.3389/fpls.2022.927746 Text en Copyright © 2022 De Backer, Van Breusegem and De Clercq. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Plant Science De Backer, Jonas Van Breusegem, Frank De Clercq, Inge Proteolytic Activation of Plant Membrane-Bound Transcription Factors |
title | Proteolytic Activation of Plant Membrane-Bound Transcription Factors |
title_full | Proteolytic Activation of Plant Membrane-Bound Transcription Factors |
title_fullStr | Proteolytic Activation of Plant Membrane-Bound Transcription Factors |
title_full_unstemmed | Proteolytic Activation of Plant Membrane-Bound Transcription Factors |
title_short | Proteolytic Activation of Plant Membrane-Bound Transcription Factors |
title_sort | proteolytic activation of plant membrane-bound transcription factors |
topic | Plant Science |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237531/ https://www.ncbi.nlm.nih.gov/pubmed/35774815 http://dx.doi.org/10.3389/fpls.2022.927746 |
work_keys_str_mv | AT debackerjonas proteolyticactivationofplantmembraneboundtranscriptionfactors AT vanbreusegemfrank proteolyticactivationofplantmembraneboundtranscriptionfactors AT declercqinge proteolyticactivationofplantmembraneboundtranscriptionfactors |