An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms

As an inorganic small molecule pollutant, the toxicity and potential carcinogenicity of hydrazine (N(2)H(4)) are of increasing concern. In this work, A water-soluble fluorescent probe (OCYB) based on the intramolecular charge transfer (ICT) mechanism for the detection of hydrazine was designed and s...

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Autores principales: Liu, Xina, Zhu, Meiqing, Xu, Chenyang, Fan, Fugang, Chen, Panpan, Wang, Yi, Li, Dongyang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Bioengineering and Biotechnology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237640/
https://www.ncbi.nlm.nih.gov/pubmed/35774058
http://dx.doi.org/10.3389/fbioe.2022.937489
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author Liu, Xina
Zhu, Meiqing
Xu, Chenyang
Fan, Fugang
Chen, Panpan
Wang, Yi
Li, Dongyang
author_facet Liu, Xina
Zhu, Meiqing
Xu, Chenyang
Fan, Fugang
Chen, Panpan
Wang, Yi
Li, Dongyang
author_sort Liu, Xina
collection PubMed
description As an inorganic small molecule pollutant, the toxicity and potential carcinogenicity of hydrazine (N(2)H(4)) are of increasing concern. In this work, A water-soluble fluorescent probe (OCYB) based on the intramolecular charge transfer (ICT) mechanism for the detection of hydrazine was designed and synthesized. Taking the advantage of 4-bromobutyryl as the recognition group, the high selectivity of OCYB to N(2)H(4) was confirmed by steady-state fluorescence spectroscopy. The limit of detection (LOD) was calculated to be 78 nM in the DMSO-HEPES (pH 7.4) system. The detection mechanism was verified by NMR, HRMS and density functional theory (DFT) calculations. In addition, OCYB exhibits strong anti-interference ability and an “Off-On” fluorescence enhancement effect. Importantly, OCYB can be used to effectively monitor the fluorescence distribution of N(2)H(4) in environmental water samples and organisms.
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spelling pubmed-92376402022-06-29 An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms Liu, Xina Zhu, Meiqing Xu, Chenyang Fan, Fugang Chen, Panpan Wang, Yi Li, Dongyang Front Bioeng Biotechnol Bioengineering and Biotechnology As an inorganic small molecule pollutant, the toxicity and potential carcinogenicity of hydrazine (N(2)H(4)) are of increasing concern. In this work, A water-soluble fluorescent probe (OCYB) based on the intramolecular charge transfer (ICT) mechanism for the detection of hydrazine was designed and synthesized. Taking the advantage of 4-bromobutyryl as the recognition group, the high selectivity of OCYB to N(2)H(4) was confirmed by steady-state fluorescence spectroscopy. The limit of detection (LOD) was calculated to be 78 nM in the DMSO-HEPES (pH 7.4) system. The detection mechanism was verified by NMR, HRMS and density functional theory (DFT) calculations. In addition, OCYB exhibits strong anti-interference ability and an “Off-On” fluorescence enhancement effect. Importantly, OCYB can be used to effectively monitor the fluorescence distribution of N(2)H(4) in environmental water samples and organisms. Frontiers Media S.A. 2022-06-14 /pmc/articles/PMC9237640/ /pubmed/35774058 http://dx.doi.org/10.3389/fbioe.2022.937489 Text en Copyright © 2022 Liu, Zhu, Xu, Fan, Chen, Wang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Bioengineering and Biotechnology
Liu, Xina
Zhu, Meiqing
Xu, Chenyang
Fan, Fugang
Chen, Panpan
Wang, Yi
Li, Dongyang
An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms
title An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms
title_full An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms
title_fullStr An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms
title_full_unstemmed An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms
title_short An ICT-Based Coumarin Fluorescent Probe for the Detection of Hydrazine and Its Application in Environmental Water Samples and Organisms
title_sort ict-based coumarin fluorescent probe for the detection of hydrazine and its application in environmental water samples and organisms
topic Bioengineering and Biotechnology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9237640/
https://www.ncbi.nlm.nih.gov/pubmed/35774058
http://dx.doi.org/10.3389/fbioe.2022.937489
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