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Bone morphogenetic protein inhibitors and mitochondria targeting agents synergistically induce apoptosis-inducing factor (AIF) caspase-independent cell death in lung cancer cells

BACKGROUND: Bone morphogenetic proteins (BMP) are evolutionarily conserved morphogens that are reactivated in lung carcinomas. In lung cancer cells, BMP signaling suppresses AMP activated kinase (AMPK) by inhibiting LKB1. AMPK is activated by mitochondrial stress that inhibits ATP production, which...

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Detalles Bibliográficos
Autores principales:	Mondal, Arindam, Roberge, Jacques, Gilleran, John, Peng, Youyi, Jia, Dongxuan, Akel, Moumen, Patel, Yash, Zoltowski, Harrison, Doraiswamy, Anupama, Langenfeld, John
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238106/ https://www.ncbi.nlm.nih.gov/pubmed/35761398 http://dx.doi.org/10.1186/s12964-022-00905-4

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