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DNA methyltransferase 1 knockdown reverses PTEN and VDR by mediating demethylation of promoter and protects against renal injuries in hepatitis B virus-associated glomerulonephritis

BACKGROUND: Aberrant DNA methylation patterns, including hypermethylation of key genes that inhibit fibrosis and inflammation, have been described in human kidney diseases. However, the role of DNA methyltransferase 1 (DNMT1) in hepatitis B virus-associated glomerulonephritis (HBV-GN) remains unclea...

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Detalles Bibliográficos
Autores principales:	Guan, Haochen, Zhu, Nan, Tang, Gang, Du, Yi, Wang, Ling, Yuan, Weijie
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238139/ https://www.ncbi.nlm.nih.gov/pubmed/35765066 http://dx.doi.org/10.1186/s13578-022-00835-1

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