Cleavage of tropomodulin-3 by asparagine endopeptidase promotes cancer malignancy by actin remodeling and SND1/RhoA signaling

BACKGROUND: Abnormal proliferation and migration of cells are hallmarks of cancer initiation and malignancy. Asparagine endopeptidase (AEP) has specific substrate cleavage ability and plays a pro-cancer role in a variety of cancers. However, the underlying mechanism of AEP in cancer proliferation an...

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Detalles Bibliográficos
Autores principales: Chen, Binghong, Wang, Mengying, Qiu, Junjun, Liao, Keman, Zhang, Wenrui, Lv, Qi, Ma, Chunhui, Qian, Zhongrun, Shi, Zhonggang, Liang, Rong, Lin, Yan, Ye, Jiazhou, Qiu, Yongming, Lin, Yingying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238189/
https://www.ncbi.nlm.nih.gov/pubmed/35765111
http://dx.doi.org/10.1186/s13046-022-02411-4

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