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Kinome profiling of cholangiocarcinoma organoids reveals potential druggable targets that hold promise for treatment stratification

BACKGROUND: Cholangiocarcinoma is a rare but lethal cancer of the biliary tract. Its first-line treatment is currently restricted to chemotherapy, which provides limited clinical benefit. Kinase inhibitors targeting oncogenic intracellular signaling have changed the treatment paradigm of cancer over...

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Detalles Bibliográficos
Autores principales:	Lieshout, Ruby, Faria, Alessandra V. S., Peppelenbosch, Maikel P., van der Laan, Luc J. W., Verstegen, Monique M. A., Fuhler, Gwenny M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238224/ https://www.ncbi.nlm.nih.gov/pubmed/35764936 http://dx.doi.org/10.1186/s10020-022-00498-1

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