Mucus and Mucins: The Underappreciated Host Defence System

The mucosal surfaces that form the boundary between the external environment and the underlying tissue are protected by a mucus barrier. Mucin glycoproteins, both secreted and cell surface mucins, are the major components of the barrier. They can exclude pathogens and toxins while hosting the commen...

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Detalles Bibliográficos
Autores principales: Sheng, Yong Hua, Hasnain, Sumaira Z.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Cellular and Infection Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238349/
https://www.ncbi.nlm.nih.gov/pubmed/35774401
http://dx.doi.org/10.3389/fcimb.2022.856962
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author Sheng, Yong Hua
Hasnain, Sumaira Z.
author_facet Sheng, Yong Hua
Hasnain, Sumaira Z.
author_sort Sheng, Yong Hua
collection PubMed
description The mucosal surfaces that form the boundary between the external environment and the underlying tissue are protected by a mucus barrier. Mucin glycoproteins, both secreted and cell surface mucins, are the major components of the barrier. They can exclude pathogens and toxins while hosting the commensal bacteria. In this review, we highlight the dynamic function of the mucins and mucus during infection, how this mucosal barrier is regulated, and how pathogens have evolved mechanisms to evade this defence system.
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spelling pubmed-92383492022-06-29 Mucus and Mucins: The Underappreciated Host Defence System Sheng, Yong Hua Hasnain, Sumaira Z. Front Cell Infect Microbiol Cellular and Infection Microbiology The mucosal surfaces that form the boundary between the external environment and the underlying tissue are protected by a mucus barrier. Mucin glycoproteins, both secreted and cell surface mucins, are the major components of the barrier. They can exclude pathogens and toxins while hosting the commensal bacteria. In this review, we highlight the dynamic function of the mucins and mucus during infection, how this mucosal barrier is regulated, and how pathogens have evolved mechanisms to evade this defence system. Frontiers Media S.A. 2022-06-14 /pmc/articles/PMC9238349/ /pubmed/35774401 http://dx.doi.org/10.3389/fcimb.2022.856962 Text en Copyright © 2022 Sheng and Hasnain https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cellular and Infection Microbiology
Sheng, Yong Hua
Hasnain, Sumaira Z.
Mucus and Mucins: The Underappreciated Host Defence System
title Mucus and Mucins: The Underappreciated Host Defence System
title_full Mucus and Mucins: The Underappreciated Host Defence System
title_fullStr Mucus and Mucins: The Underappreciated Host Defence System
title_full_unstemmed Mucus and Mucins: The Underappreciated Host Defence System
title_short Mucus and Mucins: The Underappreciated Host Defence System
title_sort mucus and mucins: the underappreciated host defence system
topic Cellular and Infection Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238349/
https://www.ncbi.nlm.nih.gov/pubmed/35774401
http://dx.doi.org/10.3389/fcimb.2022.856962
work_keys_str_mv AT shengyonghua mucusandmucinstheunderappreciatedhostdefencesystem
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