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Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism

Irisin is a myokine involved in the browning of white adipose tissue and regulation of energy expenditure, glucose homeostasis and insulin sensitivity. Debated evidence exists on the metabolic role played by irisin in children with overweight or obesity, while few information exist in children with...

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Autores principales: Mai, Stefania, Fintini, Danilo, Mele, Chiara, Convertino, Alessio, Bocchini, Sarah, Grugni, Graziano, Aimaretti, Gianluca, Vietti, Roberta, Scacchi, Massimo, Crinò, Antonino, Marzullo, Paolo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238350/
https://www.ncbi.nlm.nih.gov/pubmed/35774143
http://dx.doi.org/10.3389/fendo.2022.918467
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author Mai, Stefania
Fintini, Danilo
Mele, Chiara
Convertino, Alessio
Bocchini, Sarah
Grugni, Graziano
Aimaretti, Gianluca
Vietti, Roberta
Scacchi, Massimo
Crinò, Antonino
Marzullo, Paolo
author_facet Mai, Stefania
Fintini, Danilo
Mele, Chiara
Convertino, Alessio
Bocchini, Sarah
Grugni, Graziano
Aimaretti, Gianluca
Vietti, Roberta
Scacchi, Massimo
Crinò, Antonino
Marzullo, Paolo
author_sort Mai, Stefania
collection PubMed
description Irisin is a myokine involved in the browning of white adipose tissue and regulation of energy expenditure, glucose homeostasis and insulin sensitivity. Debated evidence exists on the metabolic role played by irisin in children with overweight or obesity, while few information exist in children with Prader Willi Syndrome (PWS), a condition genetically prone to obesity. Here we assessed serum irisin in relation to the metabolic profile and body composition in children and adolescents with and without PWS. In 25 PWS subjects [age 6.6-17.8y; body mass index standard deviation score (BMI SDS) 2.5 ± 0.3] and 25 age, and BMI-matched controls (age 6.8-18.0y; BMI SDS, 2.8 ± 0.1) we assessed irisin levels and metabolic profile inclusive of oral glucose tolerance test (OGTT), and body composition by dual-energy X-ray absorptiometry (DXA). In PWS, we recorded lower levels of fat-free mass (FFM) (p <0.05), fasting (p<0.0001) and 2h post-OGTT insulin (p<0.05) and lower insulin resistance as expressed by homeostatic model of insulin resistance (HOMA-IR) (p<0.0001). Irisin levels were significantly lower in PWS group than in controls with common obesity (p<0.05). In univariate correlation analysis, positive associations linked irisin to insulin OGTT(0) (p<0.05), insulin OGTT(120) (p<0.005), HOMA-IR (p<0.05) and fasting C-peptide (p<0.05). In stepwise multivariable regression analysis, irisin levels were independently predicted by insulin OGTT(120). These results suggest a link between irisin levels and insulin sensitivity in two divergent models of obesity.
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spelling pubmed-92383502022-06-29 Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism Mai, Stefania Fintini, Danilo Mele, Chiara Convertino, Alessio Bocchini, Sarah Grugni, Graziano Aimaretti, Gianluca Vietti, Roberta Scacchi, Massimo Crinò, Antonino Marzullo, Paolo Front Endocrinol (Lausanne) Endocrinology Irisin is a myokine involved in the browning of white adipose tissue and regulation of energy expenditure, glucose homeostasis and insulin sensitivity. Debated evidence exists on the metabolic role played by irisin in children with overweight or obesity, while few information exist in children with Prader Willi Syndrome (PWS), a condition genetically prone to obesity. Here we assessed serum irisin in relation to the metabolic profile and body composition in children and adolescents with and without PWS. In 25 PWS subjects [age 6.6-17.8y; body mass index standard deviation score (BMI SDS) 2.5 ± 0.3] and 25 age, and BMI-matched controls (age 6.8-18.0y; BMI SDS, 2.8 ± 0.1) we assessed irisin levels and metabolic profile inclusive of oral glucose tolerance test (OGTT), and body composition by dual-energy X-ray absorptiometry (DXA). In PWS, we recorded lower levels of fat-free mass (FFM) (p <0.05), fasting (p<0.0001) and 2h post-OGTT insulin (p<0.05) and lower insulin resistance as expressed by homeostatic model of insulin resistance (HOMA-IR) (p<0.0001). Irisin levels were significantly lower in PWS group than in controls with common obesity (p<0.05). In univariate correlation analysis, positive associations linked irisin to insulin OGTT(0) (p<0.05), insulin OGTT(120) (p<0.005), HOMA-IR (p<0.05) and fasting C-peptide (p<0.05). In stepwise multivariable regression analysis, irisin levels were independently predicted by insulin OGTT(120). These results suggest a link between irisin levels and insulin sensitivity in two divergent models of obesity. Frontiers Media S.A. 2022-06-14 /pmc/articles/PMC9238350/ /pubmed/35774143 http://dx.doi.org/10.3389/fendo.2022.918467 Text en Copyright © 2022 Mai, Fintini, Mele, Convertino, Bocchini, Grugni, Aimaretti, Vietti, Scacchi, Crinò and Marzullo https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Mai, Stefania
Fintini, Danilo
Mele, Chiara
Convertino, Alessio
Bocchini, Sarah
Grugni, Graziano
Aimaretti, Gianluca
Vietti, Roberta
Scacchi, Massimo
Crinò, Antonino
Marzullo, Paolo
Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism
title Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism
title_full Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism
title_fullStr Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism
title_full_unstemmed Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism
title_short Circulating Irisin in Children and Adolescents With Prader-Willi Syndrome: Relation With Glucose Metabolism
title_sort circulating irisin in children and adolescents with prader-willi syndrome: relation with glucose metabolism
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238350/
https://www.ncbi.nlm.nih.gov/pubmed/35774143
http://dx.doi.org/10.3389/fendo.2022.918467
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