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Single-Fluorescence ATP Sensor Based on Fluorescence Resonance Energy Transfer Reveals Role of Antibiotic-Induced ATP Perturbation in Mycobacterial Killing

The rapid emergence of multidrug-resistant/extensively drug-resistant tuberculosis (TB) is responsible for treatment failure in patients with TB and significantly endangers global public health. Recently, bioenergetics has become a new paradigm for anti-TB drug discovery and is based on the link bet...

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Detalles Bibliográficos
Autores principales: Liang, Lujie, Lin, Daixi, Chen, Yishen, Li, Jiachen, Liang, Wanfei, Zhao, Hui, Luo, Wenji, Tian, Guo-bao, Feng, Siyuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238375/
https://www.ncbi.nlm.nih.gov/pubmed/35615956
http://dx.doi.org/10.1128/msystems.00209-22