DNase 1 Protects From Increased Thrombin Generation and Venous Thrombosis During Aging: Cross‐Sectional Study in Mice and Humans

BACKGROUND: Human aging is associated with increased risk of thrombosis, but the mechanisms are poorly defined. We hypothesized that aging induces peroxide‐dependent release of neutrophil extracellular traps that contribute to thrombin generation and thrombosis. METHODS AND RESULTS: We studied C57BL...

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Detalles Bibliográficos
Autores principales: Kumar, Rahul, Sonkar, Vijay K., Swamy, Jagadish, Ahmed, Azaj, Sharathkumar, Anjali A., Pierce, Gary L., Dayal, Sanjana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238525/
https://www.ncbi.nlm.nih.gov/pubmed/35023342
http://dx.doi.org/10.1161/JAHA.121.021188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238525/
https://www.ncbi.nlm.nih.gov/pubmed/35023342
http://dx.doi.org/10.1161/JAHA.121.021188

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