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Cardiorenal Effects of Long‐Term Phosphodiesterase V Inhibition in Pre–Heart Failure

BACKGROUND: Phosphodiesterase V (PDEV) is upregulated in heart failure, leading to increased degradation of cGMP and impaired natriuresis. PDEV inhibition improves the renal response to B‐type natriuretic peptide in animal models. We tested the hypothesis that long‐term PDEV inhibition would improve...

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Detalles Bibliográficos
Autores principales:	Hubers, Scott A., Wan, Siu‐Hin, Adel, Fadi W., Benike, Sherry L., Burnett, John C., Scott, Christopher, Chen, Horng H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2022
Materias:	Original Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238526/ https://www.ncbi.nlm.nih.gov/pubmed/35001638 http://dx.doi.org/10.1161/JAHA.121.022126

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