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Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure

BACKGROUND: Although multiorgan networks are involved in the pathophysiology of heart failure (HF), interactions of the heart and the liver have not been fully understood. Hepatokines, which are synthesized and secreted from the liver, have regulatory functions in peripheral tissues. Here, we aimed...

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Autores principales: Takeishi, Ryohei, Misaka, Tomofumi, Ichijo, Yasuhiro, Ishibashi, Shinji, Matsuda, Mitsuko, Yamadera, Yukio, Ohara, Himika, Sugawara, Yukiko, Hotsuki, Yu, Watanabe, Koichiro, Anzai, Fumiya, Sato, Yu, Sato, Takamasa, Oikawa, Masayoshi, Kobayashi, Atsushi, Yamaki, Takayoshi, Nakazato, Kazuhiko, Yoshihisa, Akiomi, Takeishi, Yasuchika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238692/
https://www.ncbi.nlm.nih.gov/pubmed/35621211
http://dx.doi.org/10.1161/JAHA.121.024901
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author Takeishi, Ryohei
Misaka, Tomofumi
Ichijo, Yasuhiro
Ishibashi, Shinji
Matsuda, Mitsuko
Yamadera, Yukio
Ohara, Himika
Sugawara, Yukiko
Hotsuki, Yu
Watanabe, Koichiro
Anzai, Fumiya
Sato, Yu
Sato, Takamasa
Oikawa, Masayoshi
Kobayashi, Atsushi
Yamaki, Takayoshi
Nakazato, Kazuhiko
Yoshihisa, Akiomi
Takeishi, Yasuchika
author_facet Takeishi, Ryohei
Misaka, Tomofumi
Ichijo, Yasuhiro
Ishibashi, Shinji
Matsuda, Mitsuko
Yamadera, Yukio
Ohara, Himika
Sugawara, Yukiko
Hotsuki, Yu
Watanabe, Koichiro
Anzai, Fumiya
Sato, Yu
Sato, Takamasa
Oikawa, Masayoshi
Kobayashi, Atsushi
Yamaki, Takayoshi
Nakazato, Kazuhiko
Yoshihisa, Akiomi
Takeishi, Yasuchika
author_sort Takeishi, Ryohei
collection PubMed
description BACKGROUND: Although multiorgan networks are involved in the pathophysiology of heart failure (HF), interactions of the heart and the liver have not been fully understood. Hepatokines, which are synthesized and secreted from the liver, have regulatory functions in peripheral tissues. Here, we aimed to clarify the clinical impact of the hepatokine selenoprotein P in patients with HF. METHODS AND RESULTS: This is a prospective observational study that enrolled 296 participants consisting of 253 hospitalized patients with HF and 43 control subjects. First, we investigated selenoprotein P levels and found that its levels were significantly higher in patients with HF than in the controls. Next, patients with HF were categorized into 4 groups according to the presence of liver congestion using shear wave elastography and liver hypoperfusion by peak systolic velocity of the celiac artery, which were both assessed by abdominal ultrasonography. Selenoprotein P levels were significantly elevated in patients with HF with liver hypoperfusion compared with those without but were not different between the patients with and without liver congestion. Selenoprotein P levels were negatively correlated with peak systolic velocity of the celiac artery, whereas no correlations were observed between selenoprotein P levels and shear wave elastography of the liver. Kaplan‐Meier analysis demonstrated that patients with HF with higher selenoprotein P levels were significantly associated with increased adverse cardiac outcomes including cardiac deaths and worsening HF. CONCLUSIONS: Liver‐derived selenoprotein P correlates with hepatic hypoperfusion and may be a novel target involved in cardiohepatic interactions as well as a useful biomarker for predicting prognosis in patients with HF.
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spelling pubmed-92386922022-06-30 Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure Takeishi, Ryohei Misaka, Tomofumi Ichijo, Yasuhiro Ishibashi, Shinji Matsuda, Mitsuko Yamadera, Yukio Ohara, Himika Sugawara, Yukiko Hotsuki, Yu Watanabe, Koichiro Anzai, Fumiya Sato, Yu Sato, Takamasa Oikawa, Masayoshi Kobayashi, Atsushi Yamaki, Takayoshi Nakazato, Kazuhiko Yoshihisa, Akiomi Takeishi, Yasuchika J Am Heart Assoc Original Research BACKGROUND: Although multiorgan networks are involved in the pathophysiology of heart failure (HF), interactions of the heart and the liver have not been fully understood. Hepatokines, which are synthesized and secreted from the liver, have regulatory functions in peripheral tissues. Here, we aimed to clarify the clinical impact of the hepatokine selenoprotein P in patients with HF. METHODS AND RESULTS: This is a prospective observational study that enrolled 296 participants consisting of 253 hospitalized patients with HF and 43 control subjects. First, we investigated selenoprotein P levels and found that its levels were significantly higher in patients with HF than in the controls. Next, patients with HF were categorized into 4 groups according to the presence of liver congestion using shear wave elastography and liver hypoperfusion by peak systolic velocity of the celiac artery, which were both assessed by abdominal ultrasonography. Selenoprotein P levels were significantly elevated in patients with HF with liver hypoperfusion compared with those without but were not different between the patients with and without liver congestion. Selenoprotein P levels were negatively correlated with peak systolic velocity of the celiac artery, whereas no correlations were observed between selenoprotein P levels and shear wave elastography of the liver. Kaplan‐Meier analysis demonstrated that patients with HF with higher selenoprotein P levels were significantly associated with increased adverse cardiac outcomes including cardiac deaths and worsening HF. CONCLUSIONS: Liver‐derived selenoprotein P correlates with hepatic hypoperfusion and may be a novel target involved in cardiohepatic interactions as well as a useful biomarker for predicting prognosis in patients with HF. John Wiley and Sons Inc. 2022-06-27 /pmc/articles/PMC9238692/ /pubmed/35621211 http://dx.doi.org/10.1161/JAHA.121.024901 Text en © 2022 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Takeishi, Ryohei
Misaka, Tomofumi
Ichijo, Yasuhiro
Ishibashi, Shinji
Matsuda, Mitsuko
Yamadera, Yukio
Ohara, Himika
Sugawara, Yukiko
Hotsuki, Yu
Watanabe, Koichiro
Anzai, Fumiya
Sato, Yu
Sato, Takamasa
Oikawa, Masayoshi
Kobayashi, Atsushi
Yamaki, Takayoshi
Nakazato, Kazuhiko
Yoshihisa, Akiomi
Takeishi, Yasuchika
Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure
title Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure
title_full Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure
title_fullStr Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure
title_full_unstemmed Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure
title_short Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure
title_sort increases in hepatokine selenoprotein p levels are associated with hepatic hypoperfusion and predict adverse prognosis in patients with heart failure
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9238692/
https://www.ncbi.nlm.nih.gov/pubmed/35621211
http://dx.doi.org/10.1161/JAHA.121.024901
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