Structure-Guided Synthesis of FK506 and FK520 Analogs with Increased Selectivity Exhibit In Vivo Therapeutic Efficacy against Cryptococcus

Calcineurin is an essential virulence factor that is conserved across human fungal pathogens, including Cryptococcus neoformans, Aspergillus fumigatus, and Candida albicans. Although an excellent target for antifungal drug development, the serine-threonine phosphatase activity of calcineurin is cons...

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Detalles Bibliográficos
Autores principales: Hoy, Michael J., Park, Eunchong, Lee, Hyunji, Lim, Won Young, Cole, D. Christopher, DeBouver, Nicholas D., Bobay, Benjamin G., Pierce, Phillip G., Fox, David, Ciofani, Maria, Juvvadi, Praveen R., Steinbach, William, Hong, Jiyong, Heitman, Joseph
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239059/
https://www.ncbi.nlm.nih.gov/pubmed/35604094
http://dx.doi.org/10.1128/mbio.01049-22

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