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PKR Binds Enterovirus IRESs, Displaces Host Translation Factors, and Impairs Viral Translation to Enable Innate Antiviral Signaling

For RNA virus families except Picornaviridae, viral RNA sensing includes Toll-like receptors and/or RIG-I. Picornavirus RNAs, whose 5′ termini are shielded by a genome-linked protein, are predominately recognized by MDA5. This has important ramifications for adaptive immunity, as MDA5-specific patte...

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Detalles Bibliográficos
Autores principales:	Dobrikov, Mikhail I., Dobrikova, Elena Y., McKay, Zachary P., Kastan, Jonathan P., Brown, Michael C., Gromeier, Matthias
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239082/ https://www.ncbi.nlm.nih.gov/pubmed/35652592 http://dx.doi.org/10.1128/mbio.00854-22

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