C6 Hydroxymethyl-Substituted Carbapenem MA-1-206 Inhibits the Major Acinetobacter baumannii Carbapenemase OXA-23 by Impeding Deacylation

Acinetobacter baumannii has become a major nosocomial pathogen, as it is often multidrug-resistant, which results in infections characterized by high mortality rates. The bacterium achieves high levels of resistance to β-lactam antibiotics by producing β-lactamases, enzymes which destroy these valua...

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Detalles Bibliográficos
Autores principales: Stewart, Nichole K., Toth, Marta, Alqurafi, Maha A., Chai, Weirui, Nguyen, Thu Q., Quan, Pojun, Lee, Mijoon, Buynak, John D., Smith, Clyde A., Vakulenko, Sergei B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239083/
https://www.ncbi.nlm.nih.gov/pubmed/35420470
http://dx.doi.org/10.1128/mbio.00367-22

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