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Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)

The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The i...

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Autores principales: Bretagne, Stéphane, Sitbon, Karine, Desnos-Ollivier, Marie, Garcia-Hermoso, Dea, Letscher-Bru, Valérie, Cassaing, Sophie, Millon, Laurence, Morio, Florent, Gangneux, Jean-Pierre, Hasseine, Lilia, Favennec, Loïc, Cateau, Estelle, Bailly, Eric, Moniot, Maxime, Bonhomme, Julie, Desbois-Nogard, Nicole, Chouaki, Taieb, Paugam, André, Bouteille, Bernard, Pihet, Marc, Dalle, Frédéric, Eloy, Odile, Sasso, Milène, Demar, Magalie, Mariani-Kurkdjian, Patricia, Robert, Vincent, Lortholary, Olivier, Dromer, Françoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239099/
https://www.ncbi.nlm.nih.gov/pubmed/35499498
http://dx.doi.org/10.1128/mbio.00920-22
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author Bretagne, Stéphane
Sitbon, Karine
Desnos-Ollivier, Marie
Garcia-Hermoso, Dea
Letscher-Bru, Valérie
Cassaing, Sophie
Millon, Laurence
Morio, Florent
Gangneux, Jean-Pierre
Hasseine, Lilia
Favennec, Loïc
Cateau, Estelle
Bailly, Eric
Moniot, Maxime
Bonhomme, Julie
Desbois-Nogard, Nicole
Chouaki, Taieb
Paugam, André
Bouteille, Bernard
Pihet, Marc
Dalle, Frédéric
Eloy, Odile
Sasso, Milène
Demar, Magalie
Mariani-Kurkdjian, Patricia
Robert, Vincent
Lortholary, Olivier
Dromer, Françoise
author_facet Bretagne, Stéphane
Sitbon, Karine
Desnos-Ollivier, Marie
Garcia-Hermoso, Dea
Letscher-Bru, Valérie
Cassaing, Sophie
Millon, Laurence
Morio, Florent
Gangneux, Jean-Pierre
Hasseine, Lilia
Favennec, Loïc
Cateau, Estelle
Bailly, Eric
Moniot, Maxime
Bonhomme, Julie
Desbois-Nogard, Nicole
Chouaki, Taieb
Paugam, André
Bouteille, Bernard
Pihet, Marc
Dalle, Frédéric
Eloy, Odile
Sasso, Milène
Demar, Magalie
Mariani-Kurkdjian, Patricia
Robert, Vincent
Lortholary, Olivier
Dromer, Françoise
author_sort Bretagne, Stéphane
collection PubMed
description The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% (P < 0.0001). Yeast fungemia (n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia (n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P < 0.0001). Invasive aspergillosis (n = 1,661) and mucormycosis (n = 314) were diagnosed mostly in hematology (>60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools.
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spelling pubmed-92390992022-06-29 Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018) Bretagne, Stéphane Sitbon, Karine Desnos-Ollivier, Marie Garcia-Hermoso, Dea Letscher-Bru, Valérie Cassaing, Sophie Millon, Laurence Morio, Florent Gangneux, Jean-Pierre Hasseine, Lilia Favennec, Loïc Cateau, Estelle Bailly, Eric Moniot, Maxime Bonhomme, Julie Desbois-Nogard, Nicole Chouaki, Taieb Paugam, André Bouteille, Bernard Pihet, Marc Dalle, Frédéric Eloy, Odile Sasso, Milène Demar, Magalie Mariani-Kurkdjian, Patricia Robert, Vincent Lortholary, Olivier Dromer, Françoise mBio Research Article The French National Reference Center for Invasive Mycoses and Antifungals leads an active and sustained nationwide surveillance program on probable and proven invasive fungal diseases (IFDs) to determine their epidemiology in France. Between 2012 and 2018, a total of 10,886 IFDs were recorded. The incidence increased slightly over time (2.16 to 2.36/10,000 hospitalization days, P = 0.0562) in relation with an increase of fungemia incidence (1.03 to 1.19/10,000, P = 0.0023), while that of other IFDs remained stable. The proportion of ≥65-year-old patients increased from 38.4% to 45.3% (P < 0.0001). Yeast fungemia (n = 5,444) was due mainly to Candida albicans (55.6%) with stable proportions of species over time. Echinocandins became the main drug prescribed (46.7% to 61.8%), but global mortality rate remained unchanged (36.3% at 1 month). Pneumocystis jirovecii pneumonia (n = 2,106) was diagnosed mostly in HIV-negative patients (80.7%) with a significantly higher mortality than in HIV-positive patients (21.9% versus 5.4% at 1 month, P < 0.0001). Invasive aspergillosis (n = 1,661) and mucormycosis (n = 314) were diagnosed mostly in hematology (>60% of the cases) with a global mortality rate of 42.5% and 59.3%, respectively, at 3 months and significant changes in diagnosis procedure over time. More concurrent infections were also diagnosed over time (from 5.4% to 9.4% for mold IFDs, P = 0.0115). In conclusion, we observed an aging of patients with IFD with a significant increase in incidence only for yeast fungemia, a trend toward more concurrent infections, which raises diagnostic and therapeutic issues. Overall, global survival associated with IFDs has not improved despite updated guidelines and new diagnostic tools. American Society for Microbiology 2022-05-02 /pmc/articles/PMC9239099/ /pubmed/35499498 http://dx.doi.org/10.1128/mbio.00920-22 Text en Copyright © 2022 Bretagne et al. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Research Article
Bretagne, Stéphane
Sitbon, Karine
Desnos-Ollivier, Marie
Garcia-Hermoso, Dea
Letscher-Bru, Valérie
Cassaing, Sophie
Millon, Laurence
Morio, Florent
Gangneux, Jean-Pierre
Hasseine, Lilia
Favennec, Loïc
Cateau, Estelle
Bailly, Eric
Moniot, Maxime
Bonhomme, Julie
Desbois-Nogard, Nicole
Chouaki, Taieb
Paugam, André
Bouteille, Bernard
Pihet, Marc
Dalle, Frédéric
Eloy, Odile
Sasso, Milène
Demar, Magalie
Mariani-Kurkdjian, Patricia
Robert, Vincent
Lortholary, Olivier
Dromer, Françoise
Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)
title Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)
title_full Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)
title_fullStr Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)
title_full_unstemmed Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)
title_short Active Surveillance Program to Increase Awareness on Invasive Fungal Diseases: the French RESSIF Network (2012 to 2018)
title_sort active surveillance program to increase awareness on invasive fungal diseases: the french ressif network (2012 to 2018)
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239099/
https://www.ncbi.nlm.nih.gov/pubmed/35499498
http://dx.doi.org/10.1128/mbio.00920-22
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