Human Cytomegalovirus IE2 Both Activates and Represses Initiation and Modulates Elongation in a Context-Dependent Manner

Human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is a multifunctional transcription factor that is essential for lytic HCMV infection. IE2 functions as an activator of viral early genes, negatively regulates its own promoter, and is required for viral replication. The mechanisms by which...

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Detalles Bibliográficos
Autores principales: Ball, Christopher B., Li, Ming, Parida, Mrutyunjaya, Hu, Qiaolin, Ince, Deniz, Collins, Geoffrey S., Meier, Jeffery L., Price, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239164/
https://www.ncbi.nlm.nih.gov/pubmed/35579393
http://dx.doi.org/10.1128/mbio.00337-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239164/
https://www.ncbi.nlm.nih.gov/pubmed/35579393
http://dx.doi.org/10.1128/mbio.00337-22

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