Cargando…

Human Cytomegalovirus IE2 Both Activates and Represses Initiation and Modulates Elongation in a Context-Dependent Manner

Human cytomegalovirus (HCMV) immediate-early 2 (IE2) protein is a multifunctional transcription factor that is essential for lytic HCMV infection. IE2 functions as an activator of viral early genes, negatively regulates its own promoter, and is required for viral replication. The mechanisms by which...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ball, Christopher B., Li, Ming, Parida, Mrutyunjaya, Hu, Qiaolin, Ince, Deniz, Collins, Geoffrey S., Meier, Jeffery L., Price, David H.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239164/ https://www.ncbi.nlm.nih.gov/pubmed/35579393 http://dx.doi.org/10.1128/mbio.00337-22

Ejemplares similares

Cytomegalovirus late transcription factor target sequence diversity orchestrates viral early to late transcription
por: Li, Ming, et al.
Publicado: (2021)

Human cytomegalovirus IE2 drives transcription initiation from a select subset of late infection viral promoters by host RNA polymerase II
por: Li, Ming, et al.
Publicado: (2020)

Nucleotide Resolution Comparison of Transcription of Human Cytomegalovirus and Host Genomes Reveals Universal Use of RNA Polymerase II Elongation Control Driven by Dissimilar Core Promoter Elements
por: Parida, Mrutyunjaya, et al.
Publicado: (2019)

Differences in RNA polymerase II complexes and their interactions with surrounding chromatin on human and cytomegalovirus genomes
por: Spector, Benjamin M., et al.
Publicado: (2022)

Human Cytomegalovirus Infection Elicits Global Changes in Host Transcription by RNA Polymerases I, II, and III
por: Ball, Christopher B., et al.
Publicado: (2022)

Sobre las íes : antología personal /
por: Deniz, Gerardo, 1934-2014
Publicado: (2008)

Differential dependencies of human RNA polymerase II promoters on TBP, TAF1, TFIIB and XPB
por: Santana, Juan F, et al.
Publicado: (2022)

Cross-Species Analysis of Innate Immune Antagonism by Cytomegalovirus IE1 Protein
por: Rothemund, Franziska, et al.
Publicado: (2022)

Analysis of Human Cytomegalovirus-Encoded SUMO Targets and Temporal Regulation of SUMOylation of the Immediate-Early Proteins IE1 and IE2 during Infection
por: Kim, Eui Tae, et al.
Publicado: (2014)

Identification of compounds with anti-human cytomegalovirus activity that inhibit production of IE2 proteins
por: Beelontally, Rooksarr, et al.
Publicado: (2017)

Human Cytomegalovirus Genomes Survive Mitosis via the IE19 Chromatin-Tethering Domain
por: Lyon, Shelby M., et al.
Publicado: (2020)

Non-covalent Interaction With SUMO Enhances the Activity of Human Cytomegalovirus Protein IE1
por: Tripathi, Vasvi, et al.
Publicado: (2021)

Human Cytomegalovirus-IE2 Affects Embryonic Liver Development and Survival in Transgenic Mouse
por: Zhang, Xianjuan, et al.
Publicado: (2022)

Human Cytomegalovirus IE2 Disrupts Neural Progenitor Development and Induces Microcephaly in Transgenic Mouse
por: Niu, Delei, et al.
Publicado: (2023)

Human cytomegalovirus IE1 protein alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome
por: Fang, Qianglin, et al.
Publicado: (2016)

Correction: Human cytomegalovirus IE1 alters the higher-order chromatin structure by targeting the acidic patch of the nucleosome
por: Fang, Qianglin, et al.
Publicado: (2016)

Detection of Human cytomegalovirus UL55 Gene and IE/E Protein Expression in Colorectal Cancer Patients in Egypt
por: Raouf, May, et al.
Publicado: (2023)

Oral microbiomes of patients with infective endocarditis (IE): a comparative pilot study of IE patients, patients at risk for IE and healthy controls
por: Mougeot, Jean-Luc C., et al.
Publicado: (2022)

121. Cardiac Implantable Electronic Device-Related Infective Endocarditis (CIED-IE): Clinical Features and Outcomes of Patients with Definite IE Who Fulfill Both Major Duke Criteria
por: Gupta, Siddhi, et al.
Publicado: (2019)

Protective CD8+ T-cell responses to cytomegalovirus driven by rAAV/GFP/IE1 loading of dendritic cells
por: Yu, Yuefei, et al.
Publicado: (2008)

The Cellular Protein MCM3AP Is Required for Inhibition of Cellular DNA Synthesis by the IE86 Protein of Human Cytomegalovirus
por: Poole, Emma, et al.
Publicado: (2012)

Interaction Network of Proteins Associated with Human Cytomegalovirus IE2-p86 Protein during Infection: A Proteomic Analysis
por: Du, Guixin, et al.
Publicado: (2013)

The Carboxy Terminal Region of the Human Cytomegalovirus Immediate Early 1 (IE1) Protein Disrupts Type II Inteferon Signaling
por: Raghavan, Bindu, et al.
Publicado: (2014)

Crystal Structure of Cytomegalovirus IE1 Protein Reveals Targeting of TRIM Family Member PML via Coiled-Coil Interactions
por: Scherer, Myriam, et al.
Publicado: (2014)

Human cytomegalovirus IE1 downregulates Hes1 in neural progenitor cells as a potential E3 ubiquitin ligase
por: Liu, Xi-Juan, et al.
Publicado: (2017)

Characteristics of Immediate-Early 2 (IE2) and UL84 Proteins in UL84-Independent Strains of Human Cytomegalovirus (HCMV)
por: Manska, Salome, et al.
Publicado: (2021)

The Dm-Myb Oncoprotein Contributes to Insulator Function and Stabilizes Repressive H3K27me3 PcG Domains
por: Santana, Juan F., et al.
Publicado: (2020)

Nuclear export restricts Gdown1 to a mitotic function
por: Ball, Christopher B, et al.
Publicado: (2022)

Hox genes control vertebrate body elongation by collinear Wnt repression
por: Denans, Nicolas, et al.
Publicado: (2015)

Hypocotyl Elongation Inhibition of Melatonin Is Involved in Repressing Brassinosteroid Biosynthesis in Arabidopsis
por: Xiong, Fangjie, et al.
Publicado: (2019)

The effect of murine cytomegalovirus IE-3 specific shRNA is dependent on intragenic target site due to multiple transcription initiation sites
por: Marshall, Brendan, et al.
Publicado: (2011)

Ablation of the Regulatory IE1 Protein of Murine Cytomegalovirus Alters In Vivo Pro-inflammatory TNF-alpha Production during Acute Infection
por: Rodríguez-Martín, Sara, et al.
Publicado: (2012)

Human cytomegalovirus IE1 promoter/enhancer drives variable gene expression in all fiber types in transgenic mouse skeletal muscle
por: Hallauer, Patricia L, et al.
Publicado: (2000)

The Major Immediate-Early Protein IE2 of Human Cytomegalovirus Is Sufficient to Induce Proteasomal Degradation of CD83 on Mature Dendritic Cells
por: Heilingloh, Christiane S., et al.
Publicado: (2017)

An Early Immediate Early Protein IE-1–Specific T-Cell Polyfunctionality Is Associated With a Better Control of Cytomegalovirus Reactivation in Kidney Transplantation
por: Dekeyser, Manon, et al.
Publicado: (2017)

Cytomegalovirus Downregulates IRE1 to Repress the Unfolded Protein Response
por: Stahl, Sebastian, et al.
Publicado: (2013)

Epigramas & [i.e. y] epitafios /
por: Gambetta, Fredy, 1947-
Publicado: (1975)

Mason Awarded IES Silver Medal
Publicado: (1996)

9 [i.e. Neun] Symphonien
por: Dvorák, Antonín, 1841-1904
Publicado: (1987)

Human Cytomegalovirus IE1 Protein Enhances Herpes Simplex Virus Type 1-induced Syncytial Formation in U373MG Cells
por: Shin, Ki-Chul, et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_7kflksb699cs4bkh2k3dl16kat