Cargando…

Meaningful Use of Pathogen Genomic Data

Population genomic analysis is a powerful tool to understand the evolutionary history of pathogens and the factors contributing to the success or failure of lineages. These studies have significant implications for human health, as evident from our ongoing tracking of SARS-CoV-2. In their article, G...

Descripción completa

Detalles Bibliográficos
Autor principal: Azarian, Taj
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239187/
https://www.ncbi.nlm.nih.gov/pubmed/35467413
http://dx.doi.org/10.1128/mbio.00311-22
_version_ 1784737237075755008
author Azarian, Taj
author_facet Azarian, Taj
author_sort Azarian, Taj
collection PubMed
description Population genomic analysis is a powerful tool to understand the evolutionary history of pathogens and the factors contributing to the success or failure of lineages. These studies have significant implications for human health, as evident from our ongoing tracking of SARS-CoV-2. In their article, Gill et al. (J. L. Gill, J. Hedge, D. J. Wilson, and R. C. MacLean, mBio 12:e02168-21, 2021, https://doi.org/10.1128/mBio.02168-21) demonstrate the utility of pathogen genomic data by comprehensively elucidating the origin of methicillin-resistant Staphylococcus aureus ST239. To accomplish this, they leveraged newly developed tools for querying large genomic data sets. Overall, these analyses rely on the availability of representative genomic data along with their associated metadata—information about where and when samples were collected, clinical and epidemiological characteristics, and phenotypic properties. However, in many instances, these data are missing. Here, I borrow the term “meaningful use” from the Health IT field to describe the need to maximize the utility of genomic data and make suggestions for how to address the current limitations.
format Online
Article
Text
id pubmed-9239187
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-92391872022-06-29 Meaningful Use of Pathogen Genomic Data Azarian, Taj mBio Commentary Population genomic analysis is a powerful tool to understand the evolutionary history of pathogens and the factors contributing to the success or failure of lineages. These studies have significant implications for human health, as evident from our ongoing tracking of SARS-CoV-2. In their article, Gill et al. (J. L. Gill, J. Hedge, D. J. Wilson, and R. C. MacLean, mBio 12:e02168-21, 2021, https://doi.org/10.1128/mBio.02168-21) demonstrate the utility of pathogen genomic data by comprehensively elucidating the origin of methicillin-resistant Staphylococcus aureus ST239. To accomplish this, they leveraged newly developed tools for querying large genomic data sets. Overall, these analyses rely on the availability of representative genomic data along with their associated metadata—information about where and when samples were collected, clinical and epidemiological characteristics, and phenotypic properties. However, in many instances, these data are missing. Here, I borrow the term “meaningful use” from the Health IT field to describe the need to maximize the utility of genomic data and make suggestions for how to address the current limitations. American Society for Microbiology 2022-04-25 /pmc/articles/PMC9239187/ /pubmed/35467413 http://dx.doi.org/10.1128/mbio.00311-22 Text en Copyright © 2022 Azarian. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Azarian, Taj
Meaningful Use of Pathogen Genomic Data
title Meaningful Use of Pathogen Genomic Data
title_full Meaningful Use of Pathogen Genomic Data
title_fullStr Meaningful Use of Pathogen Genomic Data
title_full_unstemmed Meaningful Use of Pathogen Genomic Data
title_short Meaningful Use of Pathogen Genomic Data
title_sort meaningful use of pathogen genomic data
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239187/
https://www.ncbi.nlm.nih.gov/pubmed/35467413
http://dx.doi.org/10.1128/mbio.00311-22
work_keys_str_mv AT azariantaj meaningfuluseofpathogengenomicdata