Cargando…

What Causes the Cough in Whooping Cough?

What causes the cough in whooping cough (pertussis) has been a longstanding question in the field but has been difficult to answer because of the perceived lack of convenient small animal models. Y. Hiramatsu, K. Suzuki, T. Nishida, N. Onoda, et al. (mBio 13:e01397-21, 2022, https://doi.org/10.1128/...

Descripción completa

Detalles Bibliográficos
Autor principal: Carbonetti, Nicholas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239215/
https://www.ncbi.nlm.nih.gov/pubmed/35604095
http://dx.doi.org/10.1128/mbio.00917-22
_version_ 1784737245841850368
author Carbonetti, Nicholas
author_facet Carbonetti, Nicholas
author_sort Carbonetti, Nicholas
collection PubMed
description What causes the cough in whooping cough (pertussis) has been a longstanding question in the field but has been difficult to answer because of the perceived lack of convenient small animal models. Y. Hiramatsu, K. Suzuki, T. Nishida, N. Onoda, et al. (mBio 13:e01397-21, 2022, https://doi.org/10.1128/mbio.03197-21) used a mouse model and cellular studies to investigate bacterial and host factors that contribute to cough production during Bordetella pertussis infection. In elegant studies, they found that the bacterial factors pertussis toxin, lipooligosaccharide, and Vag8 function cooperatively to produce cough. These factors induce production of host bradykinin, a known cough inducer that sensitizes the ion channel TRPV1 on neurons, and they investigated host signaling pathways altered by the bacterial factors that exacerbate cough responses. This is a highly significant and important finding that not only elucidates mechanisms underlying the pathophysiology of the severe cough, but also may reveal potential novel therapeutic approaches to treat individuals suffering from the debilitating effects of cough in pertussis.
format Online
Article
Text
id pubmed-9239215
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher American Society for Microbiology
record_format MEDLINE/PubMed
spelling pubmed-92392152022-06-29 What Causes the Cough in Whooping Cough? Carbonetti, Nicholas mBio Commentary What causes the cough in whooping cough (pertussis) has been a longstanding question in the field but has been difficult to answer because of the perceived lack of convenient small animal models. Y. Hiramatsu, K. Suzuki, T. Nishida, N. Onoda, et al. (mBio 13:e01397-21, 2022, https://doi.org/10.1128/mbio.03197-21) used a mouse model and cellular studies to investigate bacterial and host factors that contribute to cough production during Bordetella pertussis infection. In elegant studies, they found that the bacterial factors pertussis toxin, lipooligosaccharide, and Vag8 function cooperatively to produce cough. These factors induce production of host bradykinin, a known cough inducer that sensitizes the ion channel TRPV1 on neurons, and they investigated host signaling pathways altered by the bacterial factors that exacerbate cough responses. This is a highly significant and important finding that not only elucidates mechanisms underlying the pathophysiology of the severe cough, but also may reveal potential novel therapeutic approaches to treat individuals suffering from the debilitating effects of cough in pertussis. American Society for Microbiology 2022-05-23 /pmc/articles/PMC9239215/ /pubmed/35604095 http://dx.doi.org/10.1128/mbio.00917-22 Text en Copyright © 2022 Carbonetti. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Commentary
Carbonetti, Nicholas
What Causes the Cough in Whooping Cough?
title What Causes the Cough in Whooping Cough?
title_full What Causes the Cough in Whooping Cough?
title_fullStr What Causes the Cough in Whooping Cough?
title_full_unstemmed What Causes the Cough in Whooping Cough?
title_short What Causes the Cough in Whooping Cough?
title_sort what causes the cough in whooping cough?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239215/
https://www.ncbi.nlm.nih.gov/pubmed/35604095
http://dx.doi.org/10.1128/mbio.00917-22
work_keys_str_mv AT carbonettinicholas whatcausesthecoughinwhoopingcough