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Monoclonal Antibodies and Flaviviruses: a Possible Option?
M. P. Doyle, J. R. Genualdi, A. L. Bailey, N. Kose, et al. (mBio 13:e00512-22, 2022, https://doi.org/10.1128/mBio.00512-22), report on the cloning of a panel of fully human monoclonal antibodies (mAbs) directed against yellow fever virus (YFV). In particular, mAb YFV-136 is endowed with interesting...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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American Society for Microbiology
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239274/ https://www.ncbi.nlm.nih.gov/pubmed/35575500 http://dx.doi.org/10.1128/mbio.00824-22 |
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author | Mancini, Nicasio |
author_facet | Mancini, Nicasio |
author_sort | Mancini, Nicasio |
collection | PubMed |
description | M. P. Doyle, J. R. Genualdi, A. L. Bailey, N. Kose, et al. (mBio 13:e00512-22, 2022, https://doi.org/10.1128/mBio.00512-22), report on the cloning of a panel of fully human monoclonal antibodies (mAbs) directed against yellow fever virus (YFV). In particular, mAb YFV-136 is endowed with interesting cross-YFV substrain-neutralizing features. The importance of YFV-136 and other mAbs with similar characteristics is related not necessarily only to their possible future use in the clinic but also to their role in a better understanding of the biology of YFV (as well as of other flaviviruses) for the development of effective therapeutic and prophylactic strategies. The emergence and reemergence of different flaviviruses worldwide in the last decades certainly make this a compelling clinical priority. |
format | Online Article Text |
id | pubmed-9239274 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | American Society for Microbiology |
record_format | MEDLINE/PubMed |
spelling | pubmed-92392742022-06-29 Monoclonal Antibodies and Flaviviruses: a Possible Option? Mancini, Nicasio mBio Commentary M. P. Doyle, J. R. Genualdi, A. L. Bailey, N. Kose, et al. (mBio 13:e00512-22, 2022, https://doi.org/10.1128/mBio.00512-22), report on the cloning of a panel of fully human monoclonal antibodies (mAbs) directed against yellow fever virus (YFV). In particular, mAb YFV-136 is endowed with interesting cross-YFV substrain-neutralizing features. The importance of YFV-136 and other mAbs with similar characteristics is related not necessarily only to their possible future use in the clinic but also to their role in a better understanding of the biology of YFV (as well as of other flaviviruses) for the development of effective therapeutic and prophylactic strategies. The emergence and reemergence of different flaviviruses worldwide in the last decades certainly make this a compelling clinical priority. American Society for Microbiology 2022-05-16 /pmc/articles/PMC9239274/ /pubmed/35575500 http://dx.doi.org/10.1128/mbio.00824-22 Text en Copyright © 2022 Mancini. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Commentary Mancini, Nicasio Monoclonal Antibodies and Flaviviruses: a Possible Option? |
title | Monoclonal Antibodies and Flaviviruses: a Possible Option? |
title_full | Monoclonal Antibodies and Flaviviruses: a Possible Option? |
title_fullStr | Monoclonal Antibodies and Flaviviruses: a Possible Option? |
title_full_unstemmed | Monoclonal Antibodies and Flaviviruses: a Possible Option? |
title_short | Monoclonal Antibodies and Flaviviruses: a Possible Option? |
title_sort | monoclonal antibodies and flaviviruses: a possible option? |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239274/ https://www.ncbi.nlm.nih.gov/pubmed/35575500 http://dx.doi.org/10.1128/mbio.00824-22 |
work_keys_str_mv | AT mancininicasio monoclonalantibodiesandflavivirusesapossibleoption |