Cargando…

Exploring Ganweikang Tablet as a Candidate Drug for NAFLD Through Network Pharmacology Analysis and Experimental Validation

Nonalcoholic fatty liver disease (NAFLD) is defined as liver disease in which more than 5% of hepatocytes are steatotic with little or no alcohol consumption. NAFLD includes benign nonalcoholic fatty liver (NAFL) and nonalcoholic steatohepatitis (NASH). Importantly, NASH is an advanced progression o...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ma, Chuanrui, Wang, Xinyu, Zhang, Jing, Zhao, Yun, Hua, Yunqing, Zhang, Chao, Zheng, Guobin, Yang, Guangyan, Guan, Jianli, Li, Huahuan, Li, Meng, Kang, Lin, Xiang, Jiaqing, Fan, Guanwei, Yang, Shu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Pharmacology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239345/ https://www.ncbi.nlm.nih.gov/pubmed/35774609 http://dx.doi.org/10.3389/fphar.2022.893336

Ejemplares similares

Mechanisms of Ganweikang Tablets against Chronic Hepatitis B: A Comprehensive Study of Network Analysis, Molecular Docking, and Chemical Profiling
por: Xu, Jia-Qi, et al.
Publicado: (2023)

Pterostilbene Alleviates Cholestasis by Promoting SIRT1 Activity in Hepatocytes and Macrophages
por: Ma, Chuanrui, et al.
Publicado: (2021)

Astragalus Flavone Ameliorates Atherosclerosis and Hepatic Steatosis Via Inhibiting Lipid-Disorder and Inflammation in apoE(−/−) Mice
por: Ma, Chuanrui, et al.
Publicado: (2020)

Exploring potential mechanism of ciwujia tablets for insomnia by UPLC-Q-TOF-MS/MS, network pharmacology, and experimental validation
por: Liu, Hongda, et al.
Publicado: (2022)

Chaihu Shugan powder alleviates liver inflammation and hepatic steatosis in NAFLD mice: A network pharmacology study and in vivo experimental validation
por: Lei, Sisi, et al.
Publicado: (2022)

Inhibition of Podocytes DPP4 Activity Is a Potential Mechanism of Lobeliae Chinensis Herba in Treating Diabetic Kidney Disease
por: Wang, Xinyu, et al.
Publicado: (2021)

Network Pharmacology-Based Approach Uncovers the Mechanism of GuanXinNing Tablet for Treating Thrombus by MAPKs Signal Pathway
por: Wang, Mu-Lan, et al.
Publicado: (2020)

The Induction of Endothelial Autophagy and Its Role in the Development of Atherosclerosis
por: Hua, Yunqing, et al.
Publicado: (2022)

Clinical Evidence-Guided Anti-rheumatoid Arthritis Study of Shuji Tablet in Adjuvant-Induced Arthritis Rats and Mechanism Exploration via Network Pharmacological Approach
por: Dai, Weibo, et al.
Publicado: (2021)

Evaluation of the pharmacological effects and exploration of the mechanism of traditional Chinese medicine preparation Ciwujia tablets in treating insomnia based on ethology, energy metabolism, and urine metabolomic approaches
por: Liu, Hongda, et al.
Publicado: (2022)

Identification of the Main Active Components and Mechanism of Wang Bi Tablet in Treating Rheumatoid Arthritis Based on Integrative Pharmacology
por: Jiao, Yuanyuan, et al.
Publicado: (2021)

GLSP and GLSP-derived triterpenes attenuate atherosclerosis and aortic calcification by stimulating ABCA1/G1-mediated macrophage cholesterol efflux and inactivating RUNX2-mediated VSMC osteogenesis
por: Zheng, Guobin, et al.
Publicado: (2023)

Prediction of VEGF-C as a Key Target of Pure Total Flavonoids From Citrus Against NAFLD in Mice via Network Pharmacology
por: Hong, Wei, et al.
Publicado: (2019)

Exploration of the Specific Pathology of HXMM Tablet Against Retinal Injury Based on Drug Attack Model to Network Robustness
por: Xi, Yujie, et al.
Publicado: (2022)

Identification of a potent NAFLD drug candidate for controlling T2DM-mediated inflammation and secondary damage in vitro and in vivo
por: Samsuzzaman, Md, et al.
Publicado: (2022)

Obeticholic Acid Induces Hepatoxicity Via FXR in the NAFLD Mice
por: Lin, Chuangzhen, et al.
Publicado: (2022)

An Integrated Strategy to Identify and Quantify the Quality Markers of Xinkeshu Tablets Based on Spectrum-Effect Relationship, Network Pharmacology, Plasma Pharmacochemistry, and Pharmacodynamics of Zebrafish
por: Wei, Yongheng, et al.
Publicado: (2022)

A Combined Phytochemistry and Network Pharmacology Approach to Reveal the Effective Substances and Mechanisms of Wei-Fu-Chun Tablet in the Treatment of Precancerous Lesions of Gastric Cancer
por: Wang, Huijun, et al.
Publicado: (2020)

Integrated Metabolomics and Network Pharmacology Revealed Hong-Hua-Xiao-Yao Tablet’s Effect of Mediating Hormone Synthesis in the Treatment of Mammary Gland Hyperplasia
por: Gao, Ziqing, et al.
Publicado: (2022)

NAFLD and Diabetes: Two Sides of the Same Coin? Rationale for Gene-Based Personalized NAFLD Treatment
por: Xia, Ming-Feng, et al.
Publicado: (2019)

Study and exploration of the pharmacokinetics of traditional Tibetan medicine Ruyi Zhenbao tablets after single and long-term administration
por: Hou, Hongping, et al.
Publicado: (2022)

Comprehensive Metabolomics and Network Pharmacology to Explore the Mechanism of 5-Hydroxymethyl Furfural in the Treatment of Blood Deficiency Syndrome
por: Zhang, Wensen, et al.
Publicado: (2022)

Network Pharmacology and Experimental Assessment to Explore the Pharmacological Mechanism of Qimai Feiluoping Decoction Against Pulmonary Fibrosis
por: Yang, Yingying, et al.
Publicado: (2021)

Uncovering the pharmacological mechanisms of Zizhu ointment against diabetic ulcer by integrating network analysis and experimental evaluation in vivo and in vitro
por: Wang, Jie, et al.
Publicado: (2022)

Roles of hepatic stellate cells in NAFLD: From the perspective of inflammation and fibrosis
por: Wang, Man, et al.
Publicado: (2022)

Network Pharmacology-Based Strategy to Investigate the Pharmacologic Mechanisms of Atractylodes macrocephala Koidz. for the Treatment of Chronic Gastritis
por: Yang, Songhong, et al.
Publicado: (2020)

Chlorogenic Acid Improves NAFLD by Regulating gut Microbiota and GLP-1
por: Shi, Ameng, et al.
Publicado: (2021)

Danlu tongdu tablets: Preclinical safety evaluation and mechanism of hepatotoxicity
por: Zhang, Haijing, et al.
Publicado: (2022)

Prevalence Estimates for Pharmacological Neuroenhancement in Austrian University Students: Its Relation to Health-Related Risk Attitude and the Framing Effect of Caffeine Tablets
por: Dietz, Pavel, et al.
Publicado: (2018)

Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation
por: Liu, Minglu, et al.
Publicado: (2022)

Characterization of the Components and Pharmacological Effects of Mountain-Cultivated Ginseng and Garden Ginseng Based on the Integrative Pharmacology Strategy
por: Li, Sen, et al.
Publicado: (2021)

Anti-atherosclerotic effects of naringenin and quercetin from Folium Artemisiae argyi by attenuating Interleukin-1 beta (IL-1β)/ matrix metalloproteinase 9 (MMP9): network pharmacology-based analysis and validation
por: Zhang, Lei, et al.
Publicado: (2023)

Wenxin Keli for the Treatment of Arrhythmia—Systems Pharmacology and In Vivo Pharmacological Assessment
por: Li, Xiaofeng, et al.
Publicado: (2021)

Network Pharmacology-Guided Development of a Novel Integrative Regimen to Prevent Acute Graft-vs.-Host Disease
por: Lyu, Ming, et al.
Publicado: (2018)

Knowledge, Attitude, and Practice of Metformin Extended-Release Tablets Among Clinicians in China: A Cross-Sectional Survey
por: Liu, Chang, et al.
Publicado: (2021)

Corrigendum: Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation
por: Liu, Minglu, et al.
Publicado: (2023)

Deciphering the Pharmacological Mechanisms of Ma Xing Shi Gan Decoction against COVID-19 through Integrating Network Pharmacology and Experimental Exploration
por: Li, Qianqian, et al.
Publicado: (2020)

Comparison of efficacy of anti-diabetics on non-diabetic NAFLD: A network meta-analysis
por: Jin, Dachuan, et al.
Publicado: (2023)

Synergistic Effects of Cryptotanshinone and Senkyunolide I in Guanxinning Tablet Against Endogenous Thrombus Formation in Zebrafish
por: Li, Jun, et al.
Publicado: (2021)

Effects of various interventions on non-alcoholic fatty liver disease (NAFLD): A systematic review and network meta-analysis
por: Wang, Xinchen, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ks01dtcq81p8guc5sjis31uanr