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Comparative analysis of dCas9-VP64 variants and multiplexed guide RNAs mediating CRISPR activation
CRISPR/Cas9-mediated transcriptional activation (CRISPRa) is a powerful tool for investigating complex biological phenomena. Although CRISPRa approaches based on the VP64 transcriptional activator have been widely studied in both cultured cells and in animal models and exhibit great versatility for...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2022
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239446/ https://www.ncbi.nlm.nih.gov/pubmed/35763517 http://dx.doi.org/10.1371/journal.pone.0270008 |