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Advanced parental age is an independent risk factor for term low birth weight and macrosomia

We aimed to investigate association between parental age and the risks of term low birth weight and macrosomia. This was a retrospective cohort study using a national database including 2,245,785 term singleton live births with complete parental age data. Old parental age was defined as 35 years or...

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Autores principales: Chung, Yoo Hyun, Hwang, In Sun, Jung, Gyul, Ko, Hyun Sun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239628/
https://www.ncbi.nlm.nih.gov/pubmed/35777059
http://dx.doi.org/10.1097/MD.0000000000029846
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author Chung, Yoo Hyun
Hwang, In Sun
Jung, Gyul
Ko, Hyun Sun
author_facet Chung, Yoo Hyun
Hwang, In Sun
Jung, Gyul
Ko, Hyun Sun
author_sort Chung, Yoo Hyun
collection PubMed
description We aimed to investigate association between parental age and the risks of term low birth weight and macrosomia. This was a retrospective cohort study using a national database including 2,245,785 term singleton live births with complete parental age data. Old parental age was defined as 35 years or older. Odd ratios (OR) for term low birth weight and macrosomia were analyzed using univariate and multivariate logistic regression analysis. Neonatal sex, maternal occupation, parity, nationality, age, and paternal age were significant factors of term low birth weight and macrosomia, in univariate analysis. In multivariate analysis, old maternal age (≥35 years old) showed increased odds of term low birth weight and macrosomia (aOR = 1.122, 95% CI: 1.083 –1.162; and aOR = 1.166, 95% CI: 1.143 – 1.189, respectively). Similarly, old paternal age (≥35 years old) showed increased odds of term low birth weight and macrosomia (aOR = 1.090, 95% CI: 1.058 –1.122; and aOR = 1.101, 95% CI: 1.083 – 1.119, respectively). Maternal education that lasted more than 12 years had reduced odds of term low birth weight and macrosomia (OR = 0.817, 95% CI: 0.792 –0.842; and OR = 0.894, 95% CI: 0.879 – 0.91, respectively). Paternal education that lasted more than 12 years also had reduced odds of term low birth weight and macrosomia (OR = 0.865, 95% CI: 0.84 –0.892; and OR = 0.897, 95% CI: 0.881 – 0.913, respectively). This study suggests that not only maternal age but also paternal age are significantly associated with term low birth weight and macrosomia. In addition, parental education levels are also associated with term low birth weight and macrosomia.
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spelling pubmed-92396282022-06-30 Advanced parental age is an independent risk factor for term low birth weight and macrosomia Chung, Yoo Hyun Hwang, In Sun Jung, Gyul Ko, Hyun Sun Medicine (Baltimore) Research Article We aimed to investigate association between parental age and the risks of term low birth weight and macrosomia. This was a retrospective cohort study using a national database including 2,245,785 term singleton live births with complete parental age data. Old parental age was defined as 35 years or older. Odd ratios (OR) for term low birth weight and macrosomia were analyzed using univariate and multivariate logistic regression analysis. Neonatal sex, maternal occupation, parity, nationality, age, and paternal age were significant factors of term low birth weight and macrosomia, in univariate analysis. In multivariate analysis, old maternal age (≥35 years old) showed increased odds of term low birth weight and macrosomia (aOR = 1.122, 95% CI: 1.083 –1.162; and aOR = 1.166, 95% CI: 1.143 – 1.189, respectively). Similarly, old paternal age (≥35 years old) showed increased odds of term low birth weight and macrosomia (aOR = 1.090, 95% CI: 1.058 –1.122; and aOR = 1.101, 95% CI: 1.083 – 1.119, respectively). Maternal education that lasted more than 12 years had reduced odds of term low birth weight and macrosomia (OR = 0.817, 95% CI: 0.792 –0.842; and OR = 0.894, 95% CI: 0.879 – 0.91, respectively). Paternal education that lasted more than 12 years also had reduced odds of term low birth weight and macrosomia (OR = 0.865, 95% CI: 0.84 –0.892; and OR = 0.897, 95% CI: 0.881 – 0.913, respectively). This study suggests that not only maternal age but also paternal age are significantly associated with term low birth weight and macrosomia. In addition, parental education levels are also associated with term low birth weight and macrosomia. Lippincott Williams & Wilkins 2022-06-30 /pmc/articles/PMC9239628/ /pubmed/35777059 http://dx.doi.org/10.1097/MD.0000000000029846 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Chung, Yoo Hyun
Hwang, In Sun
Jung, Gyul
Ko, Hyun Sun
Advanced parental age is an independent risk factor for term low birth weight and macrosomia
title Advanced parental age is an independent risk factor for term low birth weight and macrosomia
title_full Advanced parental age is an independent risk factor for term low birth weight and macrosomia
title_fullStr Advanced parental age is an independent risk factor for term low birth weight and macrosomia
title_full_unstemmed Advanced parental age is an independent risk factor for term low birth weight and macrosomia
title_short Advanced parental age is an independent risk factor for term low birth weight and macrosomia
title_sort advanced parental age is an independent risk factor for term low birth weight and macrosomia
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239628/
https://www.ncbi.nlm.nih.gov/pubmed/35777059
http://dx.doi.org/10.1097/MD.0000000000029846
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