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Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer
AbstractEnhancer RNAs (eRNAs) can participate in enhancer regulation and target gene transcription, thus affecting the occurrence and development of tumors. In this study, we identified eRNAs closely related to bladder cancer (BLCA). Gene expression profiles and clinical information from The Cancer...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Lippincott Williams & Wilkins
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239636/ https://www.ncbi.nlm.nih.gov/pubmed/35776987 http://dx.doi.org/10.1097/MD.0000000000029759 |
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author | Zhang, Lei Ding, Degang Liu, Jianjun Liu, Junfeng Wang, Ning Liu, Jie |
author_facet | Zhang, Lei Ding, Degang Liu, Jianjun Liu, Junfeng Wang, Ning Liu, Jie |
author_sort | Zhang, Lei |
collection | PubMed |
description | AbstractEnhancer RNAs (eRNAs) can participate in enhancer regulation and target gene transcription, thus affecting the occurrence and development of tumors. In this study, we identified eRNAs closely related to bladder cancer (BLCA). Gene expression profiles and clinical information from The Cancer Genome Atlas (TCGA) database were used in this study. The Atlas of Noncoding RNAs in Cancer (TANRIC) co-expression data was also studied to evaluate correlations between the inferred levels of eRNA and its predicted target genes. Moreover, we evaluated differences in tumor microenvironment between high and low ID2-AS1 expression groups, and predicted the response of high- and low-expression groups to immune checkpoint inhibitor (ICI) treatment. Finally, we analyzed the prognostic value of ID2-AS1 in different tumors. ID2-AS1 and ID2 were identified as eRNAs and target genes related to the prognosis of BLCA. Low ID2-AS1 levels were associated with advanced age, low overall survival, high histological grade, and late BLCA staging. ID2-AS1 appeared to regulate epithelial mesenchymal transition, mitotic spindle assembly, and angiogenesis, thereby affecting BLCA progression. The ID2-AS1 high-expression group had better ICI treatment response. In addition, ID2-AS1 also had prognostic value in other cancers. ID2-AS1 helps predict prognostic and immunotherapeutic effects in BLCA. |
format | Online Article Text |
id | pubmed-9239636 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-92396362022-06-30 Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer Zhang, Lei Ding, Degang Liu, Jianjun Liu, Junfeng Wang, Ning Liu, Jie Medicine (Baltimore) Research Article AbstractEnhancer RNAs (eRNAs) can participate in enhancer regulation and target gene transcription, thus affecting the occurrence and development of tumors. In this study, we identified eRNAs closely related to bladder cancer (BLCA). Gene expression profiles and clinical information from The Cancer Genome Atlas (TCGA) database were used in this study. The Atlas of Noncoding RNAs in Cancer (TANRIC) co-expression data was also studied to evaluate correlations between the inferred levels of eRNA and its predicted target genes. Moreover, we evaluated differences in tumor microenvironment between high and low ID2-AS1 expression groups, and predicted the response of high- and low-expression groups to immune checkpoint inhibitor (ICI) treatment. Finally, we analyzed the prognostic value of ID2-AS1 in different tumors. ID2-AS1 and ID2 were identified as eRNAs and target genes related to the prognosis of BLCA. Low ID2-AS1 levels were associated with advanced age, low overall survival, high histological grade, and late BLCA staging. ID2-AS1 appeared to regulate epithelial mesenchymal transition, mitotic spindle assembly, and angiogenesis, thereby affecting BLCA progression. The ID2-AS1 high-expression group had better ICI treatment response. In addition, ID2-AS1 also had prognostic value in other cancers. ID2-AS1 helps predict prognostic and immunotherapeutic effects in BLCA. Lippincott Williams & Wilkins 2022-06-30 /pmc/articles/PMC9239636/ /pubmed/35776987 http://dx.doi.org/10.1097/MD.0000000000029759 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal. |
spellingShingle | Research Article Zhang, Lei Ding, Degang Liu, Jianjun Liu, Junfeng Wang, Ning Liu, Jie Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer |
title | Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer |
title_full | Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer |
title_fullStr | Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer |
title_full_unstemmed | Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer |
title_short | Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer |
title_sort | identification of prognostic and immunotherapy-related erna id2-as1 in bladder cancer |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239636/ https://www.ncbi.nlm.nih.gov/pubmed/35776987 http://dx.doi.org/10.1097/MD.0000000000029759 |
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