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Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer

AbstractEnhancer RNAs (eRNAs) can participate in enhancer regulation and target gene transcription, thus affecting the occurrence and development of tumors. In this study, we identified eRNAs closely related to bladder cancer (BLCA). Gene expression profiles and clinical information from The Cancer...

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Autores principales: Zhang, Lei, Ding, Degang, Liu, Jianjun, Liu, Junfeng, Wang, Ning, Liu, Jie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239636/
https://www.ncbi.nlm.nih.gov/pubmed/35776987
http://dx.doi.org/10.1097/MD.0000000000029759
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author Zhang, Lei
Ding, Degang
Liu, Jianjun
Liu, Junfeng
Wang, Ning
Liu, Jie
author_facet Zhang, Lei
Ding, Degang
Liu, Jianjun
Liu, Junfeng
Wang, Ning
Liu, Jie
author_sort Zhang, Lei
collection PubMed
description AbstractEnhancer RNAs (eRNAs) can participate in enhancer regulation and target gene transcription, thus affecting the occurrence and development of tumors. In this study, we identified eRNAs closely related to bladder cancer (BLCA). Gene expression profiles and clinical information from The Cancer Genome Atlas (TCGA) database were used in this study. The Atlas of Noncoding RNAs in Cancer (TANRIC) co-expression data was also studied to evaluate correlations between the inferred levels of eRNA and its predicted target genes. Moreover, we evaluated differences in tumor microenvironment between high and low ID2-AS1 expression groups, and predicted the response of high- and low-expression groups to immune checkpoint inhibitor (ICI) treatment. Finally, we analyzed the prognostic value of ID2-AS1 in different tumors. ID2-AS1 and ID2 were identified as eRNAs and target genes related to the prognosis of BLCA. Low ID2-AS1 levels were associated with advanced age, low overall survival, high histological grade, and late BLCA staging. ID2-AS1 appeared to regulate epithelial mesenchymal transition, mitotic spindle assembly, and angiogenesis, thereby affecting BLCA progression. The ID2-AS1 high-expression group had better ICI treatment response. In addition, ID2-AS1 also had prognostic value in other cancers. ID2-AS1 helps predict prognostic and immunotherapeutic effects in BLCA.
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spelling pubmed-92396362022-06-30 Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer Zhang, Lei Ding, Degang Liu, Jianjun Liu, Junfeng Wang, Ning Liu, Jie Medicine (Baltimore) Research Article AbstractEnhancer RNAs (eRNAs) can participate in enhancer regulation and target gene transcription, thus affecting the occurrence and development of tumors. In this study, we identified eRNAs closely related to bladder cancer (BLCA). Gene expression profiles and clinical information from The Cancer Genome Atlas (TCGA) database were used in this study. The Atlas of Noncoding RNAs in Cancer (TANRIC) co-expression data was also studied to evaluate correlations between the inferred levels of eRNA and its predicted target genes. Moreover, we evaluated differences in tumor microenvironment between high and low ID2-AS1 expression groups, and predicted the response of high- and low-expression groups to immune checkpoint inhibitor (ICI) treatment. Finally, we analyzed the prognostic value of ID2-AS1 in different tumors. ID2-AS1 and ID2 were identified as eRNAs and target genes related to the prognosis of BLCA. Low ID2-AS1 levels were associated with advanced age, low overall survival, high histological grade, and late BLCA staging. ID2-AS1 appeared to regulate epithelial mesenchymal transition, mitotic spindle assembly, and angiogenesis, thereby affecting BLCA progression. The ID2-AS1 high-expression group had better ICI treatment response. In addition, ID2-AS1 also had prognostic value in other cancers. ID2-AS1 helps predict prognostic and immunotherapeutic effects in BLCA. Lippincott Williams & Wilkins 2022-06-30 /pmc/articles/PMC9239636/ /pubmed/35776987 http://dx.doi.org/10.1097/MD.0000000000029759 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle Research Article
Zhang, Lei
Ding, Degang
Liu, Jianjun
Liu, Junfeng
Wang, Ning
Liu, Jie
Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer
title Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer
title_full Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer
title_fullStr Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer
title_full_unstemmed Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer
title_short Identification of prognostic and immunotherapy-related eRNA ID2-AS1 in bladder cancer
title_sort identification of prognostic and immunotherapy-related erna id2-as1 in bladder cancer
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239636/
https://www.ncbi.nlm.nih.gov/pubmed/35776987
http://dx.doi.org/10.1097/MD.0000000000029759
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