Cargando…

Personalized treatment of malignant tumors during pregnancy

The combination of pregnancy and cancer is a challenge for the patient and a problematic clinical dilemma for the doctor. In this retrospective observational cohort study, we have tried to analyze our experience in the management of such patients. This review includes 41 patients with malignant neop...

Descripción completa

Detalles Bibliográficos
Autores principales: Ulrikh, E., Kalinina, E., Dikareva, E., Komlichenko, E., Li, O., Zhamborova, O., Rizhinashvili, I., Dzharbaeva, A., Govorov, I., Artemenko, V., Bezrukikh, V., Salogub, G., Pervunina, T., Urmancheeva, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239643/
https://www.ncbi.nlm.nih.gov/pubmed/35777052
http://dx.doi.org/10.1097/MD.0000000000029803
_version_ 1784737347109126144
author Ulrikh, E.
Kalinina, E.
Dikareva, E.
Komlichenko, E.
Li, O.
Zhamborova, O.
Rizhinashvili, I.
Dzharbaeva, A.
Govorov, I.
Artemenko, V.
Bezrukikh, V.
Salogub, G.
Pervunina, T.
Urmancheeva, A.
author_facet Ulrikh, E.
Kalinina, E.
Dikareva, E.
Komlichenko, E.
Li, O.
Zhamborova, O.
Rizhinashvili, I.
Dzharbaeva, A.
Govorov, I.
Artemenko, V.
Bezrukikh, V.
Salogub, G.
Pervunina, T.
Urmancheeva, A.
author_sort Ulrikh, E.
collection PubMed
description The combination of pregnancy and cancer is a challenge for the patient and a problematic clinical dilemma for the doctor. In this retrospective observational cohort study, we have tried to analyze our experience in the management of such patients. This review includes 41 patients with malignant neoplasms detected during pregnancy who received treatment at the Almazov National Medical Research Centre from 2015-2021. The majority of patients received treatment during pregnancy (n=26, 63.4%): chemotherapy – 19 (46.3%) (in 2 cases in combination with surgery), surgical treatment – 7 (17, 1%) patients. In most cases, delivery was at term (n=28, 68.3%). All children born at term were mature and had no growth restriction, regardless of whether the mothers received treatment during pregnancy or not. When detecting cancer during pregnancy, an immediate follow-up examination is required to assess the extent of the tumor and current fetal state. If pregnancy prolongation is requested, the treatment should not be postponed, except for systemic chemotherapy in the first trimester of pregnancy, pelvic radiation at any term.
format Online
Article
Text
id pubmed-9239643
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Lippincott Williams & Wilkins
record_format MEDLINE/PubMed
spelling pubmed-92396432022-06-30 Personalized treatment of malignant tumors during pregnancy Ulrikh, E. Kalinina, E. Dikareva, E. Komlichenko, E. Li, O. Zhamborova, O. Rizhinashvili, I. Dzharbaeva, A. Govorov, I. Artemenko, V. Bezrukikh, V. Salogub, G. Pervunina, T. Urmancheeva, A. Medicine (Baltimore) Research Article The combination of pregnancy and cancer is a challenge for the patient and a problematic clinical dilemma for the doctor. In this retrospective observational cohort study, we have tried to analyze our experience in the management of such patients. This review includes 41 patients with malignant neoplasms detected during pregnancy who received treatment at the Almazov National Medical Research Centre from 2015-2021. The majority of patients received treatment during pregnancy (n=26, 63.4%): chemotherapy – 19 (46.3%) (in 2 cases in combination with surgery), surgical treatment – 7 (17, 1%) patients. In most cases, delivery was at term (n=28, 68.3%). All children born at term were mature and had no growth restriction, regardless of whether the mothers received treatment during pregnancy or not. When detecting cancer during pregnancy, an immediate follow-up examination is required to assess the extent of the tumor and current fetal state. If pregnancy prolongation is requested, the treatment should not be postponed, except for systemic chemotherapy in the first trimester of pregnancy, pelvic radiation at any term. Lippincott Williams & Wilkins 2022-06-30 /pmc/articles/PMC9239643/ /pubmed/35777052 http://dx.doi.org/10.1097/MD.0000000000029803 Text en Copyright © 2022 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY) (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ulrikh, E.
Kalinina, E.
Dikareva, E.
Komlichenko, E.
Li, O.
Zhamborova, O.
Rizhinashvili, I.
Dzharbaeva, A.
Govorov, I.
Artemenko, V.
Bezrukikh, V.
Salogub, G.
Pervunina, T.
Urmancheeva, A.
Personalized treatment of malignant tumors during pregnancy
title Personalized treatment of malignant tumors during pregnancy
title_full Personalized treatment of malignant tumors during pregnancy
title_fullStr Personalized treatment of malignant tumors during pregnancy
title_full_unstemmed Personalized treatment of malignant tumors during pregnancy
title_short Personalized treatment of malignant tumors during pregnancy
title_sort personalized treatment of malignant tumors during pregnancy
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239643/
https://www.ncbi.nlm.nih.gov/pubmed/35777052
http://dx.doi.org/10.1097/MD.0000000000029803
work_keys_str_mv AT ulrikhe personalizedtreatmentofmalignanttumorsduringpregnancy
AT kalininae personalizedtreatmentofmalignanttumorsduringpregnancy
AT dikarevae personalizedtreatmentofmalignanttumorsduringpregnancy
AT komlichenkoe personalizedtreatmentofmalignanttumorsduringpregnancy
AT lio personalizedtreatmentofmalignanttumorsduringpregnancy
AT zhamborovao personalizedtreatmentofmalignanttumorsduringpregnancy
AT rizhinashvilii personalizedtreatmentofmalignanttumorsduringpregnancy
AT dzharbaevaa personalizedtreatmentofmalignanttumorsduringpregnancy
AT govorovi personalizedtreatmentofmalignanttumorsduringpregnancy
AT artemenkov personalizedtreatmentofmalignanttumorsduringpregnancy
AT bezrukikhv personalizedtreatmentofmalignanttumorsduringpregnancy
AT salogubg personalizedtreatmentofmalignanttumorsduringpregnancy
AT pervuninat personalizedtreatmentofmalignanttumorsduringpregnancy
AT urmancheevaa personalizedtreatmentofmalignanttumorsduringpregnancy