Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model

Mutations in the RNA helicase, DDX3X, are a leading cause of Intellectual Disability and present as DDX3X syndrome, a neurodevelopmental disorder associated with cortical malformations and autism. Yet, the cellular and molecular mechanisms by which DDX3X controls cortical development are largely unk...

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Detalles Bibliográficos
Autores principales: Hoye, Mariah L, Calviello, Lorenzo, Poff, Abigail J, Ejimogu, Nna-Emeka, Newman, Carly R, Montgomery, Maya D, Ou, Jianhong, Floor, Stephen N, Silver, Debra L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Developmental Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239684/
https://www.ncbi.nlm.nih.gov/pubmed/35762573
http://dx.doi.org/10.7554/eLife.78203

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