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Sex Differences in the Prevalence, Outcomes and Management of Hypertension

PURPOSE OF REVIEW: To review recent data on sex differences in the prevalence, outcomes and management of hypertension. RECENT FINDINGS: Although hypertension is overall more common in males, females experience a much sharper incline in blood pressure from the third decade of life and consequently t...

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Autores principales: Connelly, Paul J., Currie, Gemma, Delles, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239955/
https://www.ncbi.nlm.nih.gov/pubmed/35254589
http://dx.doi.org/10.1007/s11906-022-01183-8
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author Connelly, Paul J.
Currie, Gemma
Delles, Christian
author_facet Connelly, Paul J.
Currie, Gemma
Delles, Christian
author_sort Connelly, Paul J.
collection PubMed
description PURPOSE OF REVIEW: To review recent data on sex differences in the prevalence, outcomes and management of hypertension. RECENT FINDINGS: Although hypertension is overall more common in males, females experience a much sharper incline in blood pressure from the third decade of life and consequently the prevalence of hypertension accelerates comparatively with age. Mechanisms responsible for these blood pressure trajectories may include the sustained vascular influence of hypertensive disorders of pregnancy, interactions between the renin–angiotensin–aldosterone system and sex hormones or even psychosocial gendered factors such as socioeconomic deprivation. Moreover, the impact of hypertension is not uniform and females are at higher risk of developing a multitude of adverse cardiovascular outcomes at lower blood pressure thresholds. SUMMARY: Blood pressure is a sexually dimorphic trait and although significant differences exist in the prevalence, pathophysiology and outcomes of hypertension in males and females, limited data exist to support sex-specific blood pressure targets.
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spelling pubmed-92399552022-06-30 Sex Differences in the Prevalence, Outcomes and Management of Hypertension Connelly, Paul J. Currie, Gemma Delles, Christian Curr Hypertens Rep Hypertension and the Kidney (RM Carey, Section Editor) PURPOSE OF REVIEW: To review recent data on sex differences in the prevalence, outcomes and management of hypertension. RECENT FINDINGS: Although hypertension is overall more common in males, females experience a much sharper incline in blood pressure from the third decade of life and consequently the prevalence of hypertension accelerates comparatively with age. Mechanisms responsible for these blood pressure trajectories may include the sustained vascular influence of hypertensive disorders of pregnancy, interactions between the renin–angiotensin–aldosterone system and sex hormones or even psychosocial gendered factors such as socioeconomic deprivation. Moreover, the impact of hypertension is not uniform and females are at higher risk of developing a multitude of adverse cardiovascular outcomes at lower blood pressure thresholds. SUMMARY: Blood pressure is a sexually dimorphic trait and although significant differences exist in the prevalence, pathophysiology and outcomes of hypertension in males and females, limited data exist to support sex-specific blood pressure targets. Springer US 2022-03-07 2022 /pmc/articles/PMC9239955/ /pubmed/35254589 http://dx.doi.org/10.1007/s11906-022-01183-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Hypertension and the Kidney (RM Carey, Section Editor)
Connelly, Paul J.
Currie, Gemma
Delles, Christian
Sex Differences in the Prevalence, Outcomes and Management of Hypertension
title Sex Differences in the Prevalence, Outcomes and Management of Hypertension
title_full Sex Differences in the Prevalence, Outcomes and Management of Hypertension
title_fullStr Sex Differences in the Prevalence, Outcomes and Management of Hypertension
title_full_unstemmed Sex Differences in the Prevalence, Outcomes and Management of Hypertension
title_short Sex Differences in the Prevalence, Outcomes and Management of Hypertension
title_sort sex differences in the prevalence, outcomes and management of hypertension
topic Hypertension and the Kidney (RM Carey, Section Editor)
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9239955/
https://www.ncbi.nlm.nih.gov/pubmed/35254589
http://dx.doi.org/10.1007/s11906-022-01183-8
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