Phase separation of insulin receptor substrate 1 drives the formation of insulin/IGF-1 signalosomes

As a critical node for insulin/IGF signaling, insulin receptor substrate 1 (IRS-1) is essential for metabolic regulation. A long and unstructured C-terminal region of IRS-1 recruits downstream effectors for promoting insulin/IGF signals. However, the underlying molecular basis for this remains elusi...

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Detalles Bibliográficos
Autores principales: Gao, Xiu Kui, Rao, Xi Sheng, Cong, Xiao Xia, Sheng, Zu Kang, Sun, Yu Ting, Xu, Shui Bo, Wang, Jian Feng, Liang, Yong Heng, Lu, Lin Rong, Ouyang, Hongwei, Ge, Huiqing, Guo, Jian-sheng, Wu, Hang-jun, Sun, Qi Ming, Wu, Hao-bo, Bao, Zhang, Zheng, Li Ling, Zhou, Yi Ting
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Nature Singapore 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240053/
https://www.ncbi.nlm.nih.gov/pubmed/35764611
http://dx.doi.org/10.1038/s41421-022-00426-x

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