MYCN-driven fatty acid uptake is a metabolic vulnerability in neuroblastoma

Neuroblastoma (NB) is a childhood cancer arising from sympatho-adrenal neural crest cells. MYCN amplification is found in half of high-risk NB patients; however, no available therapies directly target MYCN. Using multi-dimensional metabolic profiling in MYCN expression systems and primary patient tu...

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Detalles Bibliográficos
Autores principales: Tao, Ling, Mohammad, Mahmoud A., Milazzo, Giorgio, Moreno-Smith, Myrthala, Patel, Tajhal D., Zorman, Barry, Badachhape, Andrew, Hernandez, Blanca E., Wolf, Amber B., Zeng, Zihua, Foster, Jennifer H., Aloisi, Sara, Sumazin, Pavel, Zu, Youli, Hicks, John, Ghaghada, Ketan B., Putluri, Nagireddy, Perini, Giovanni, Coarfa, Cristian, Barbieri, Eveline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240069/
https://www.ncbi.nlm.nih.gov/pubmed/35764645
http://dx.doi.org/10.1038/s41467-022-31331-2

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