Glutamine deficiency in solid tumor cells confers resistance to ribosomal RNA synthesis inhibitors

Ribosome biogenesis is an energetically expensive program that is dictated by nutrient availability. Here we report that nutrient deprivation severely impairs precursor ribosomal RNA (pre-rRNA) processing and leads to the accumulation of unprocessed rRNAs. Upon nutrient restoration, pre-rRNAs stored...

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Detalles Bibliográficos
Autores principales: Pan, Melvin, Zorbas, Christiane, Sugaya, Maki, Ishiguro, Kensuke, Kato, Miki, Nishida, Miyuki, Zhang, Hai-Feng, Candeias, Marco M., Okamoto, Akimitsu, Ishikawa, Takamasa, Soga, Tomoyoshi, Aburatani, Hiroyuki, Sakai, Juro, Matsumura, Yoshihiro, Suzuki, Tsutomu, Proud, Christopher G., Lafontaine, Denis L. J., Osawa, Tsuyoshi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240073/
https://www.ncbi.nlm.nih.gov/pubmed/35764642
http://dx.doi.org/10.1038/s41467-022-31418-w

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