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SHLD1 is dispensable for 53BP1-dependent V(D)J recombination but critical for productive class switch recombination

SHLD1 is part of the Shieldin (SHLD) complex, which acts downstream of 53BP1 to counteract DNA double-strand break (DSB) end resection and promote DNA repair via non-homologous end-joining (NHEJ). While 53BP1 is essential for immunoglobulin heavy chain class switch recombination (CSR), long-range V(...

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Detalles Bibliográficos
Autores principales:	Vincendeau, Estelle, Wei, Wenming, Zhang, Xuefei, Planchais, Cyril, Yu, Wei, Lenden-Hasse, Hélène, Cokelaer, Thomas, Pipoli da Fonseca, Juliana, Mouquet, Hugo, Adams, David J., Alt, Frederick W., Jackson, Stephen P., Balmus, Gabriel, Lescale, Chloé, Deriano, Ludovic
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240092/ https://www.ncbi.nlm.nih.gov/pubmed/35764636 http://dx.doi.org/10.1038/s41467-022-31287-3

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