Activity-based probe profiling of RNF12 E3 ubiquitin ligase function in Tonne-Kalscheuer syndrome

Ubiquitylation enzymes are involved in all aspects of eukaryotic biology and are frequently disrupted in disease. One example is the E3 ubiquitin ligase RNF12/RLIM, which is mutated in the developmental disorder Tønne-Kalscheuer syndrome (TOKAS). RNF12 TOKAS variants largely disrupt catalytic E3 ubi...

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Detalles Bibliográficos
Autores principales: Bustos, Francisco, Mathur, Sunil, Espejo-Serrano, Carmen, Toth, Rachel, Hastie, C James, Virdee, Satpal, Findlay, Greg M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240097/
https://www.ncbi.nlm.nih.gov/pubmed/35764390
http://dx.doi.org/10.26508/lsa.202101248

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