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Enhancement of Phosphorylation and Transport Activity of the Neuronal Glutamate Transporter Excitatory Amino Acid Transporter 3 by C3bot and a 26mer C3bot Peptide

In primary murine hippocampal neurons we investigated the regulation of EAAT3-mediated glutamate transport by the Clostridium botulinum C3 transferase C3bot and a 26mer peptide derived from full length protein. Incubation with either enzyme-competent C3bot or enzyme-deficient C3bot(156–181) peptide...

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Detalles Bibliográficos
Autores principales: Piepgras, Johannes, Rohrbeck, Astrid, Just, Ingo, Bittner, Stefan, Ahnert-Hilger, Gudrun, Höltje, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240211/
https://www.ncbi.nlm.nih.gov/pubmed/35783090
http://dx.doi.org/10.3389/fncel.2022.860823