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Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?

Globally, there are emerging cases of acute severe hepatitis of unknown origin in children. These cases have gathered increasing attention, owing to the development of acute liver failure in some cases that resulted in liver transplantation. This review briefly summarizes the outbreak and diagnostic...

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Detalles Bibliográficos
Autores principales: Li, Jing, Hu, Wei, Zhang, Ji-Yuan, Wang, Fu-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: XIA & HE Publishing Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240247/
https://www.ncbi.nlm.nih.gov/pubmed/35836759
http://dx.doi.org/10.14218/JCTH.2022.00247
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author Li, Jing
Hu, Wei
Zhang, Ji-Yuan
Wang, Fu-Sheng
author_facet Li, Jing
Hu, Wei
Zhang, Ji-Yuan
Wang, Fu-Sheng
author_sort Li, Jing
collection PubMed
description Globally, there are emerging cases of acute severe hepatitis of unknown origin in children. These cases have gathered increasing attention, owing to the development of acute liver failure in some cases that resulted in liver transplantation. This review briefly summarizes the outbreak and diagnostic criteria of the disease. We further discuss the possible causes and related mechanisms underlying its occurrence and progression, and analyze the challenges in management. Finally, this review emphasizes patient management in clinical settings and a combination of efforts to unmask the disease.
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spelling pubmed-92402472022-07-13 Pediatric Acute Severe Hepatitis of Unknown Origin: What is New? Li, Jing Hu, Wei Zhang, Ji-Yuan Wang, Fu-Sheng J Clin Transl Hepatol Review Article Globally, there are emerging cases of acute severe hepatitis of unknown origin in children. These cases have gathered increasing attention, owing to the development of acute liver failure in some cases that resulted in liver transplantation. This review briefly summarizes the outbreak and diagnostic criteria of the disease. We further discuss the possible causes and related mechanisms underlying its occurrence and progression, and analyze the challenges in management. Finally, this review emphasizes patient management in clinical settings and a combination of efforts to unmask the disease. XIA & HE Publishing Inc. 2022-06-28 2022-06-20 /pmc/articles/PMC9240247/ /pubmed/35836759 http://dx.doi.org/10.14218/JCTH.2022.00247 Text en © 2022 Authors. https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 4.0 International License (CC BY-NC 4.0), permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Li, Jing
Hu, Wei
Zhang, Ji-Yuan
Wang, Fu-Sheng
Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?
title Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?
title_full Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?
title_fullStr Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?
title_full_unstemmed Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?
title_short Pediatric Acute Severe Hepatitis of Unknown Origin: What is New?
title_sort pediatric acute severe hepatitis of unknown origin: what is new?
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9240247/
https://www.ncbi.nlm.nih.gov/pubmed/35836759
http://dx.doi.org/10.14218/JCTH.2022.00247
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